# Core 1: Non-human primate core

> **NIH NIH P01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2021 · $422,869

## Abstract

ABSTRACT – Nonhuman Primate (NHP) Core (Core 1, Leader: Dr. Guido Silvestri, Yerkes National 
Primate Research Center, Emory University) 
The most appropriate animal model to define the origin, kinetics, and impact of humoral and cellular immune- 
based strategies on viral rebound in infants following postnatal HIV-1 infection and treatment is simian 
immunodeficiency virus (SIV)/simian-human immunodeficiency virus (SHIV) infection of rhesus macaques. 
Indeed, this model is particularly well-suited for our proposed studies because pediatric models of postnatal 
transmission have been developed and used to define the pathogenesis of infant HIV-1 infection and 
prevention strategies. However, NHP studies require extensive infrastructure and unique expertise. Thus, we 
the Program's Nonhuman Primate (NHP) Core (Core 1) will coordinate and implement all the NHP experiments 
proposed by the Program's two Projects: Project 1: “Origin and predictors of viral rebound in infants”, (PI: Dr. 
Ann Chahroudi, Emory University), and Project 2: “Impact of immune-based intervention on viral rebound in 
orally SHIV-infected infant monkeys” (PI: Dr. Genevieve Fouda, Duke University). The Core will support the 
Program through the following Specific Aims: Aim 1 - Organize, coordinate, and conduct studies of infant SHIV 
reservoir and rebound; Aim 2 - Administer and monitor antiretroviral treatment (ART) in orally SHIV-infected 
infant monkeys; and Aim 3 - Perform pharmacokinetic analysis of polyclonal antibody infusions in infant 
macaques to determine the dose and administration interval for treatment of infant SHIV infection. Led by Dr. 
Guido Silvestri, the NHP Core will ensure the following that are essential to the successful completion of these 
projects: 1) adherence to regulatory procedures relevant to research with NHPs; 2) coordination and 
implementation of all animal-related procedures, including housing, immunizations of infants, nursery-rearing of 
infants, antiretroviral treatments, and sample collections for weekly viral load measurement and monthly blood 
counts; 3) proper storage and/or shipment of samples to the Projects and Cores; and 4) maintenance of a 
database of clinical health parameters. Dr. Silvestri will ensure all NHP supported research efforts are tightly 
integrated and that evolving needs of the research projects will be met. As an integral component of this 
Program, the NHP Core will provide critical support to achieve the shared goals of understanding the source, 
kinetics, and impact of immune interventions on HIV-1 rebound in postnatally infected infants.

## Key facts

- **NIH application ID:** 10194350
- **Project number:** 5P01AI131276-06
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Guido Silvestri
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $422,869
- **Award type:** 5
- **Project period:** 2017-07-24 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10194350

## Citation

> US National Institutes of Health, RePORTER application 10194350, Core 1: Non-human primate core (5P01AI131276-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10194350. Licensed CC0.

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