# Vanderbilt Vaccine and Treatment Evaluation Unit

> **NIH NIH UM1** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $12,509,936

## Abstract

ABSTRACT
The goal of this UM1 proposal is to use the remarkable research infrastructure at Vanderbilt University
Medical Center and collaborating sites (Washington University, University of Pittsburgh, and University
of Pennsylvania) to conceptualize, design, implement, and analyze clinical research studies across a
wide variety of pathogens, infectious diseases, and populations as a Vaccine and Treatment Evaluation
Unit (VTEU). Vanderbilt University Medical Center was among the first VTEUs funded and has led
pivotal studies of influenza, pertussis, pneumococcus, smallpox, and malaria vaccines. The Vanderbilt
VTEU has a proven capacity to enroll healthy populations rapidly, including participating in two NIH-
directed influenza pandemic responses since 2009, as well as expertise enrolling special populations
such as pregnant women, infants and children, adults with underlying medical comorbidities, and the
elderly. In the current application, we have expanded our ability to recruit across the lifespan and
across multiple pathogens, including increased expertise in sexually transmitted infections, malaria, and
novel approaches to conducting clinical trial visits in the home setting. The Vanderbilt VTEU has also
led efforts to train the next generation of vaccinologists and clinical trial experts in infectious diseases,
including the development of a vaccinology fellowship, participation of fellows and junior faculty in
protocol teams and data safety committees, and encouraging concept development by junior faculty.
The Vanderbilt VTEU is also committed to working collaboratively with the newly formed Infectious
Diseases Leadership Group to articulate priorities for ID research.

## Key facts

- **NIH application ID:** 10195286
- **Project number:** 3UM1AI148452-01S2
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Clarence Buddy Creech
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $12,509,936
- **Award type:** 3
- **Project period:** 2020-07-14 → 2022-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10195286

## Citation

> US National Institutes of Health, RePORTER application 10195286, Vanderbilt Vaccine and Treatment Evaluation Unit (3UM1AI148452-01S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10195286. Licensed CC0.

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