# Origins and Transformations of Signals for Circadian Regulation

> **NIH NIH R21** · BOSTON CHILDREN'S HOSPITAL · 2021 · $265,500

## Abstract

PROJECT SUMMARY
The earth’s rotation drives profound changes in our environment. Practically every tissue of the body is
synchronized to this rhythm by an internal timekeeping mechanism, the circadian clock. Desynchronization
impairs mood, cognition, and physiology—commonly experienced in shift work and jet lag. Proper exposure to
light realigns the clock with the solar day and can reverse these impairments. We have developed a new
method to access the pathway that joins the eye with the master clock in the brain. We propose to define how
information is generated within the retina and subsequently transformed as it enters clock circuitry. We expect
to provide knowledge of how physiology is tuned to environmental cycles, and of the division of labor between
retina and brain.

## Key facts

- **NIH application ID:** 10196515
- **Project number:** 1R21EY032731-01
- **Recipient organization:** BOSTON CHILDREN'S HOSPITAL
- **Principal Investigator:** Michael Tri Hoang Do
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $265,500
- **Award type:** 1
- **Project period:** 2021-05-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10196515

## Citation

> US National Institutes of Health, RePORTER application 10196515, Origins and Transformations of Signals for Circadian Regulation (1R21EY032731-01). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10196515. Licensed CC0.

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