# Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal Epidemiology

> **NIH NIH R01** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2021 · $286,076

## Abstract

ABSTRACT
 This is a competitive renewal application for U01-AA015134. The history, experience, existing
infrastructure, and experienced staff and collaborators of our South African (SA) fetal alcohol spectrum
disorders (FASD) research program present unique opportunities to better define population-based
characteristics of children with FASD and their mothers. Furthermore, the opportunity to pursue
innovative explorations into etiology of FASD in the coming five years is excellent. We will
simultaneously pursue three diverse, but complementary, aims.
 Aim 1: Screen women of childbearing age drinking in prenatal clinics for high risk drinking
and continuing study of maternal risk. While there are multiple reasons for screening, in Aim 1 the
purpose is for selective (secondary) prevention of FASD. We will initiate a case control efficacy study
(n=400) of the use of one-session motivation enhancement therapy (MET) in prenatal clinics. These
prevention activities follow from findings and experience in previous prevention efforts. Continuing
prevention activities in antenatal clinics will also facilitate recruitment of participants for cutting-edge
biomarker studies in Aim 3.
 Aim 2: Continue longitudinal studies of the trajectory of FASD in the early years of life in
two established cohorts. We will continue regularly-scheduled, follow-up evaluation of the physical
growth and cognitive/behavioral trajectory in an established cohort of 197 diagnosed children ages 6-11
years and their mothers. We will also pursue similar developmental monitoring of a second maternal/child
cohort (n= ~230 dyads) recruited over the past 2 years. Cohort 2 will be finalized in October, 2017. A
nested study of sMRI measurement will also be undertaken in a sub-sample of Cohort 1.
 Aim 3: Collect appropriate biological samples for assessing the validity and utility of alcohol
use biomarkers and markers of the role of nutrition and nutrition genetics to better assess the
interactive role of nutrition and prenatal alcohol use in severity of child outcomes and the etiology
of FASD. We will assess alcohol use via two biomarkers, ethyl glucuronide (EtG) and
phosphatidylethanol (PEth) in antenatal clinics and prevention initiatives for accurate assessment in both
longitudinal research and monitoring prevention. Self-reported alcohol use by quantity, frequency, and
gestational timing (QFT) and the AUDIT will serve as comparison data. We will also collect samples and
data for analyzing the role of nutritional components in affecting child outcomes via a combination of:
dietary intake surveys; evaluation of multiple micronutrients in plasma samples from of pregnant women;
analysis of genetic polymorphisms (SNPs) influential in metabolism, absorption, and regulation of
essential nutrients.

## Key facts

- **NIH application ID:** 10196887
- **Project number:** 5R01AA015134-14
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** Philip Alan May
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $286,076
- **Award type:** 5
- **Project period:** 2006-09-25 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10196887

## Citation

> US National Institutes of Health, RePORTER application 10196887, Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Lifespan: Continuing Prevention and Longitudinal Epidemiology (5R01AA015134-14). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10196887. Licensed CC0.

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