# Immune Monitoring Core

> **NIH NIH P01** · JOHNS HOPKINS UNIVERSITY · 2021 · $354,738

## Abstract

Immune Monitoring Core 
Project Summary 
The application of immune-based therapies to augment the anti-tumor immune responses following autologous 
and allogeneic blood or marrow transplantation (BMT) has dramatically increase over the past several years. 
Reconstitution of the immune system following BMT, GVHD, and post-grafting immunosuppression may modify 
any immunotherapeutic approach. The need to carefully evaluate, and monitor the immune response in this 
setting has become increasingly apparent. The principle objective of the Human Immunology Core (Core C) is 
to serve as the centralized resource for the assessment of immunological monitoring of immune function in 
patients enrolled on the clinical trials. While there is great diversity in the therapeutic modalities being evaluated, 
most areas strongly overlap with regard to analysis and characterization of the immune response. A wide-variety 
of techniques that enumerate and characterize T cells, assess their functional behavior ex vivo, evaluate diversity 
of the response, characterize their gene expression signature as well as visualize multidimensional data using 
novel computational methods are available to the research projects within this P01. The specific aims of the 
Immunology Core (Core C) are to: 1) Provide sophisticated immune monitoring assays for measuring 
patients’ responses to immune therapies across projects. As a part of this aim, the Human Immunology 
core (Core C) will provide guidance and expertise to all investigators for the optimal integration of new high- 
quality correlative assays developed and utilized by the Core C for dissection of immunologic mechanisms, 
establish standard operating procedures and quality control for immunological assays that will be performed by 
the project investigators and implement the technical support; 2) Conduct assays and characterize the 
immune responses for specific clinical trials. As a part of this effort, the Immune Monitoring Core will serve 
as a repository for biospecimens, maintain the database for designated clinical trials and conduct in-depth 
mechanistic analysis associated with designated clinical trials conducted under Projects 1-4.

## Key facts

- **NIH application ID:** 10197008
- **Project number:** 5P01CA225618-03
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Leo Luznik
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $354,738
- **Award type:** 5
- **Project period:** 2019-05-21 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10197008

## Citation

> US National Institutes of Health, RePORTER application 10197008, Immune Monitoring Core (5P01CA225618-03). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10197008. Licensed CC0.

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