# New York City Sickle Cell Implementation Science Consortium

> **NIH NIH U01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2021 · $753,289

## Abstract

The goal of the New York City Sickle Cell Implementation Science Consortium (NYCSIS) is to
leverage a `learning laboratory' of six hospitals and eleven ambulatory practices within the
Mount Sinai Health System (MSHS) to improve penetration of best practices for adults and
adolescents with Sickle Cell Disease (SCD). New York City has one of the largest SCD
populations in the US, and MSHS provides SCD care to over 700 adults and adolescents. The
NYCSIS team and its community partners have identified three critical knowledge-to-action
gaps: 1) improving pain management in adult emergency departments (ED), 2) reconnecting
individuals who as adults use only the ED back into longitudinal care and 3) delivering
comprehensive care in low-density (i.e. smaller numbers of people with SCD) settings with
limited access to expert SCD hematologists. Our setting and research infrastructure position us
well to address these three issues as MSHS has a robust multi-site emergency medicine
research infrastructure (with access to hundreds of adults with SCD who do not utilize primary
care) as well as low-density hospitals and community health centers where the full complement
of experts (e.g. hematologists and other specialists) are not available. We propose four aims.
Aim 1: Conduct a whole-community needs assessment to a) identify additional areas of need,
and b) for the three interventions already developed, to understand barriers and facilitators to
scaling and implementing them at each care locations; Aim 2: Design implementation research
studies that address the identified issues of importance; Aim 3: Participate in the development
of the SCD registry in collaboration with the Data Coordinating Center and NHLBI; and Aim 4:
Conduct implementation studies that test multi-modal, multi-sector interventions to a) improve
emergency care of SCD pain, b) reconnect unaffiliated adults into comprehensive care and c)
deliver comprehensive care in low SCD density settings. The NYCSIS team has the resources
and community network to rigorously collect and integrate registry data with other U01 sites,
and to execute implementation studies that address the needs of urban SCD populations,
particularly in low-density care settings with limited access to SCD experts.

## Key facts

- **NIH application ID:** 10197193
- **Project number:** 5U01HL133997-06
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Lynne D. Richardson
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $753,289
- **Award type:** 5
- **Project period:** 2016-08-05 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10197193

## Citation

> US National Institutes of Health, RePORTER application 10197193, New York City Sickle Cell Implementation Science Consortium (5U01HL133997-06). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10197193. Licensed CC0.

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