# The CAPTURE Study:  Validating a unique COPD screening tool in primary care

> **NIH NIH R01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2021 · $1,983,602

## Abstract

PROJECT SUMMARY/ABSTRACT
Most COPD patients remain unrecognized and undertreated; these individuals experience impaired health
status, acute respiratory deteriorations, increased mortality and high health care utilization. Targeted case finding
to date has generally identified patients without reference to spirometric severity or exacerbation (ECOPD) risk.
We have developed a simple case finding tool using five questions combined with selective peak expiratory flow
measurement (CAPTURE) that identifies individuals with “clinically significant COPD,” those most likely to benefit
from currently available therapies. Our long-term goal is to effectively identify these individuals so therapy can
improve health status, reduce ECOPD, and decrease morbidity. The overall objectives of this proposal are to
validate the sensitivity, specificity, and predictive value of CAPTURE to identify undiagnosed, clinically significant
COPD in a diverse primary care population; to confirm that this methodological approach can be integrated into
a variety of primary clinical care settings; and explore whether identifying these patients results in improved
COPD specific care and health status. Our central hypothesis is that CAPTURE can effectively and efficiently
identify primary care patients with undiagnosed, clinically significant COPD. The rationale for the proposed
research is that the answer to three simple questions will change the paradigm for COPD diagnosis in primary
care: 1) Is CAPTURE effective in identifying patients with clinically significant COPD; 2) Does CAPTURE work
in primary care settings; and 3) does CAPTURE make a difference in the lives of patients with previously
undiagnosed, clinically significant COPD. Guided by strong preliminary data we will pursue three specific aims:
1) We will determine the sensitivity and specificity of CAPTURE in identifying clinically significant COPD in a
broad range of primary care outpatient practices; 2) We will define the feasibility of using CAPTURE in 10
practices representing a wide range of primary care clinical settings across the US; 3) We will explore the impact
of our case finding approach in a broad range of primary care outpatient practices and evaluate practice and
patient level characteristics that are associated with COPD related care implementation and clinical outcomes.
These aims will be accomplished in a 5,000 subject cohort study in 75 primary care practices affiliated with five
primary care based research networks that provide access to previously undiagnosed patients who exhibit
ethnic, racial, socioeconomic and regional diversity. In a subset of these clinical practices we will complete a
detailed feasibility analysis of CAPTURE implementation. Our approach is highly innovative and clinically
relevant as it applies a rigorously developed, novel COPD case finding approach to identifying COPD patients
most likely to benefit from available therapy. The proposed research is significant, as the resul...

## Key facts

- **NIH application ID:** 10197199
- **Project number:** 5R01HL136682-05
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** MeiLan K Han
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,983,602
- **Award type:** 5
- **Project period:** 2017-09-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10197199

## Citation

> US National Institutes of Health, RePORTER application 10197199, The CAPTURE Study:  Validating a unique COPD screening tool in primary care (5R01HL136682-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10197199. Licensed CC0.

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