# The Mass-SIREN Group

> **NIH NIH U24** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $167,580

## Abstract

This application will create a Network Clinical Center (Hub) for the Strategies to Innovate EmeRgENcy
Care Clinical Trials Network (SIREN). We propose an integrated, collaborative team of high volume tertiary
care medical centers with expertise in emergency care clinical research. The team includes an administrative
Hub at Massachusetts General Hospital (MGH) with Spokes across the state including Baystate Medical
Center, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Boston Medical Center, Brigham &
Women's Hospital, UMass Memorial Medical Center, and St. Vincent Hospital. The Mass-SIREN Group will be
managed by a Steering Committee including leaders from each of the member hospitals. It will function
administratively as a Hub and Spoke model, but operationally as a collaborative team of medical centers. Our
team also includes nationally- and internationally-recognized leaders in neurology, cardiology, pulmonology,
hematology, and trauma; we will propose novel ideas for the SIREN network, and innovative solutions to
common problems in clinical trials including enrollment and retention. Specific Aims include:
 Aim 1: To establish an administrative Hub for the SIREN Clinical Trials Network at MGH. This Hub will
enroll in each clinical trial. Additionally it will provide administrative coordination across the entire team.
 Aim 2. To establish the Mass-SIREN Steering Committee, an integrated leadership team that will
coordinate trial management and enrollment across all of our centers.
 Aim 3. To provide our existing network of prehospital providers with the regulatory and educational
infrastructure to ensure that trained EMS teams can successfully participate in SIREN clinical trials.
 Aim 4. To further establish the Mass-SIREN Steering Committee as innovative leaders in emergency
care research. We will leverage our individual areas of expertise, our local co-investigators, and our colleagues
with subspecialty expertise to design and propose innovative trials for the entire SIREN network.
 Our academic centers have experience conducting clinical emergency care research, and all have
existing pools of trained clinical research coordinators that actively screen in the Emergency Department (ED)
to manage enrollment and protocol compliance. Our hospitals see a wide range of patients, including children,
underserved minorities, as well as those in urban, suburban, and rural settings. We include all major
prehospital providers in Boston and across Massachusetts. Finally, this application highlights our long history
of demonstrated interdisciplinary relationships, and that our team has a proven record of joint collaboration,
trial performance, and scientific publication.
 Overall, the MASS-Siren Group includes both the breadth and depth of experience and resources to be
an outstanding Network Clinical Center for SIREN.

## Key facts

- **NIH application ID:** 10197232
- **Project number:** 5U24NS100651-05
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Joshua N Goldstein
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $167,580
- **Award type:** 5
- **Project period:** 2017-07-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10197232

## Citation

> US National Institutes of Health, RePORTER application 10197232, The Mass-SIREN Group (5U24NS100651-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10197232. Licensed CC0.

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