# Metal-Catalyzed C-H Borylation: Design of New Catalysts with New Selectivities

> **NIH NIH R01** · MICHIGAN STATE UNIVERSITY · 2020 · $104,173

## Abstract

Project Title: Metal-Catalyzed C-H Borylation: Design of New Catalysts with New Selectivities
Abstract
C–H borylation is a synthetic methodology where C–H bonds in an organic molecule react
with B–H or B–B bonds forming a B–C bond. It has been widely applied in the
functionalization of sp2 C–H bonds, but examples of sp and sp3 C–H bonds have been
reported. The products of these reactions are important intermediates, which leverage the
remarkable versatility of B–C bonds for installation of other functional groups under mild
conditions. In this renewal application, we propose to advance our understanding of C–H
borylations and to orthogonally develop the methodology such that it can offer solutions to synthetic
problems faced by the biomedical community.
Some of the specific aims build on chemistry that was developed in the previous funding
cycle, while other specific aims are entirely new. Specifically, we propose to (1) the design of low-
coordination number catalysts for directed sp2 and sp3 C–H borylation; (2) The design of ligand
frameworks for meta and para C–H borylations; and (3) Hydrogenation of C–H borylated arenes and
heterocycles to achieve formal sp3 C–H borylation. We will pursue these aims through a collaborative
multi-investigator venture that bring the power of inorganic chemistry and organic synthesis to bear on
the problem.

## Key facts

- **NIH application ID:** 10197387
- **Project number:** 3R01GM063188-13S1
- **Recipient organization:** MICHIGAN STATE UNIVERSITY
- **Principal Investigator:** Milton Rudolph Smith
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $104,173
- **Award type:** 3
- **Project period:** 2001-06-01 → 2020-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10197387

## Citation

> US National Institutes of Health, RePORTER application 10197387, Metal-Catalyzed C-H Borylation: Design of New Catalysts with New Selectivities (3R01GM063188-13S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10197387. Licensed CC0.

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