# The transcription factor Miz1-mediated mechanism of lung aging

> **NIH NIH R01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2021 · $490,293

## Abstract

Project Summary/Abstract
Chronic obstructive pulmonary disease (COPD) has risen to the third leading cause of death in the US and
specific and effective therapies are not available. Age is the most important risk factor for COPD. The
mechanisms of age-related changes that lead to COPD pathogenesis are poorly understood. In this proposal,
we will study whether Miz1 epigenetically represses NF-B-dependent components of senescence-associated
secretory phenotype (SASP), which acts in cooperation with inhibition of cell cycle arrest to suppress the
senescence program, thereby preventing the development of COPD. Completion of this proposal, which includes
animal and human studies, will provide fundamental insights into the pathogenesis of COPD and thus provide
therapeutic targets.

## Key facts

- **NIH application ID:** 10198018
- **Project number:** 5R01HL141459-05
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** JING LIU
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $490,293
- **Award type:** 5
- **Project period:** 2020-03-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10198018

## Citation

> US National Institutes of Health, RePORTER application 10198018, The transcription factor Miz1-mediated mechanism of lung aging (5R01HL141459-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10198018. Licensed CC0.

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