# Chemistry Core

> **NIH NIH P50** · WASHINGTON UNIVERSITY · 2021 · $680,330

## Abstract

Abstract
The center uses novel strategies to determine the mechanism(s) of action for the anti-
depressant actions of neurosteroids. A panel of neurosteroid analogues with a range of
previously determined mechanisms of action will be synthesized in the Chemistry Core for use
in all Projects in the center. These include analogues with actions at NMDA receptors, GABAA
receptors, Ca2+- channels, and intracellular targets. New tethered compounds will be
synthesized to restrict actions to plasma-membrane channels. Existing and proposed
photoaffinity labeling neurosteroids will be prepared in the core and used in Project 1 to identify
novel sites. The core is a hub for evaluation of the impact of neurosteroids with varied cellular
actions.

## Key facts

- **NIH application ID:** 10198245
- **Project number:** 1P50MH122379-01A1
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** DOUGLAS F COVEY
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $680,330
- **Award type:** 1
- **Project period:** 2021-08-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10198245

## Citation

> US National Institutes of Health, RePORTER application 10198245, Chemistry Core (1P50MH122379-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10198245. Licensed CC0.

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