# IUSM Alzheimer's Disease Drug Discovery Center:  PTC Software

> **NIH NIH U54** · INDIANA UNIVERSITY INDIANAPOLIS · 2021 · $393,714

## Abstract

Project Summary
Overall: The strategic goal of the Indiana University School of Medicine (IUSM)
Alzheimer’s Disease Drug Discovery (ADDD) Center is to integrate sophisticated
capability for early drug discovery and contribute to a broader study of emerging
Alzheimer’s Disease target hypotheses with the goal of generating new classes of
potential therapeutics. The ADDD CENTER will establish itself as a strategic and
operational partner for the NIA AMP-AD and MODEL-AD initiatives. By design, this will
provide drug discovery capability to bridge the work in target discovery (AMP-AD) with
newly discovered lead molecules characterized in AD animal models based on human
pathology, genetics and translational biomarkers (MODEL-AD).
To accomplish the mission of the ADDD CENTER, we have assembled a team of
scientists from Indiana University, Purdue University, and the Indiana Clinical and
Translational Sciences Institute (CTSI). This team has considerable expertise in
Alzheimer’s disease biology, CNS pharmaceutical drug discovery and development,
and scientific excellence in the core discovery technologies that will drive the ADDD
CENTER’s contributions and deliverables. A key advantage and differentiated strength
of the proposed ADDD CENTER is the primary scientific coordination and
administration through IUSM. Specific Aims are:
1. Create a portfolio of characterized AD drug discovery targets representing
novel intervention hypotheses that capitalizes on significant investments in
basic research and emerging disease understanding.
2. Perform advanced pre-clinical target validation and enablement studies to
prioritize the best opportunities for therapeutic discovery.
3. Create quality and well characterized Lead molecules for targets that meet
milestone criteria and are opportunities for further translational investment.
4. Create a flexible data sharing platform to enable global researchers with data
and Target Enablement Packages to expand on the work of the ADDD CENTER.

## Key facts

- **NIH application ID:** 10198429
- **Project number:** 3U54AG065181-02S2
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Bruce T Lamb
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $393,714
- **Award type:** 3
- **Project period:** 2019-09-30 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10198429

## Citation

> US National Institutes of Health, RePORTER application 10198429, IUSM Alzheimer's Disease Drug Discovery Center:  PTC Software (3U54AG065181-02S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10198429. Licensed CC0.

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