# Wake Forest Claude D. Pepper OAIC

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2021 · $1,107,828

## Abstract

The Wake Forest Older Americans Independence Center (WF OAIC) has been funded since 1992 and has
developed and tested interventions to improve physical function and prevent disability. Our translational
perspective integrates medicine, behavioral and cognitive science, biostatistics, muscle and adipose tissue
biology, geroscience, genomics, state-of-the-art imaging, and preclinical, clinical and population approaches.
Based on our theme, Integrating pathways affecting physical function for new approaches to disability
treatment and prevention, the WF OAIC will pursue four programmatic aims:
1. Discover new common pathways contributing to age-related declines in physical function and disability;
2. Develop, evaluate, and refine strategies for disability treatment and prevention;
3. Translate proven strategies beyond the traditional academic research environment;
4. Train the next generation of research leaders focused on disability treatment and prevention.
The aims will be pursued by integrating the efforts of 4 highly productive research support cores: the Clinical
Research Core; Biostatistics and Research Information Systems Core; Integrative Biology Core; and
BioImaging Resource Core. Under the continuing and dedicated leadership of Drs. Kritchevsky and Kitzman,
the Leadership and Administrative Core will coordinate these research core activities with those of the
Research Education Component and the Pilot and Exploratory Studies Core.
The WF OAIC will use its core structure and highly integrated approach to: 1) Translate measures and
approaches from the biology of aging for disability prevention; 2) Incorporate new pathways important to
functional decline, including brain-mediated ones, into our integrated model for intervention development; 3)
Develop and test innovative approaches to optimize body composition and function in older adults; 4) Translate
OAIC approaches into clinical and community settings; and 5) Provide mentoring and support for the next
generation translational research leaders focused on disability treatment and prevention in older Americans.

## Key facts

- **NIH application ID:** 10198677
- **Project number:** 5P30AG021332-19
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** STEPHEN B. KRITCHEVSKY
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,107,828
- **Award type:** 5
- **Project period:** 2002-09-30 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10198677

## Citation

> US National Institutes of Health, RePORTER application 10198677, Wake Forest Claude D. Pepper OAIC (5P30AG021332-19). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10198677. Licensed CC0.

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