# Systems Biology Core

> **NIH NIH U19** · SEATTLE CHILDREN'S HOSPITAL · 2021 · $435,804

## Abstract

The Systems Biology Core (SBC) will serve as a computational analysis bridge between the highly
standardized data management and processing objectives of the Data Management and Analysis Core
(DMAC) and the immunological and biological analysis objectives of Project 1 and Project 2. Although the
specific biological context and many assays in Project 1 and Project 2 are distinct, the computational strategies
for hypothesis generation and correlate discovery and testing are shared. A strategic synergy between the
Projects is therefore realized by centrally locating the computational biology analytical expertise as a common
resource within the SBC as opposed to each individual Project. Additionally, the SBC will have as a unique
Aim the integration of immunological and molecular correlates and hypotheses from the two Projects. Starting
from the standardized and pre-processed data from the DMAC, the SBC will develop and apply integrative
computational algorithms to support the proposed analyses in Project 1 and Project 2.

## Key facts

- **NIH application ID:** 10198680
- **Project number:** 5U19AI128914-06
- **Recipient organization:** SEATTLE CHILDREN'S HOSPITAL
- **Principal Investigator:** DANIEL E ZAK
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $435,804
- **Award type:** 5
- **Project period:** 2017-07-19 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10198680

## Citation

> US National Institutes of Health, RePORTER application 10198680, Systems Biology Core (5U19AI128914-06). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10198680. Licensed CC0.

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