# Dual Role for Innate Lymphoid Cells in Pathogenesis of Brucellosis

> **NIH NIH R21** · UNIVERSITY OF MISSOURI-COLUMBIA · 2021 · $187,839

## Abstract

Project Summary/Abstract:
 Brucella infection causes a myriad of symptoms due to the ability of Brucella to infect almost
any organ or organ system. Innate lymphoid cells are abundant in mucosal tissues which serve
as a portal of entry for Brucella infection, and we have found that innate lymphoid cells regulate
both inflammation and control of Brucella infection. In this proposal, we will investigate interactions
between innate lymphoid cells and inflammasomes to determine how innate lymphoid cells from
different tissues regulate Brucella-induced inflammation. We will also determine the relative
contribution of different innate lymphoid cell subsets to controlling inflammation and Brucella
infection. Collectively the results of our study will enhance our understanding of how Brucella is
able to utilize mucosal sites as a portal of infection and cause inflammation within different host
tissues.

## Key facts

- **NIH application ID:** 10198734
- **Project number:** 5R21AI153074-02
- **Recipient organization:** UNIVERSITY OF MISSOURI-COLUMBIA
- **Principal Investigator:** Jerod Skyberg
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $187,839
- **Award type:** 5
- **Project period:** 2020-06-19 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10198734

## Citation

> US National Institutes of Health, RePORTER application 10198734, Dual Role for Innate Lymphoid Cells in Pathogenesis of Brucellosis (5R21AI153074-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10198734. Licensed CC0.

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