# Video Intervention to Address Pre-Test Patient Education for Tumor Genomic Testing

> **NIH NIH R21** · OHIO STATE UNIVERSITY · 2021 · $395,878

## Abstract

PROJECT SUMMARY
Thousands of patients are diagnosed with metastatic cancers each year and somatic (tumor) next generation
sequencing (NGS) testing is increasingly important for the treatment of these cancers. Professional guidelines
state that treating oncologists should discuss with patients prior to testing the possibility of incidental germline
findings and disease-specific limitations in clinical utility and interpretation of somatic (tumor) next generation
sequencing (NGS) results. However, oncologists have varied understanding of genetics and time limitations
make it challenging for providers to adequately inform their patients about tumor NGS within the context of
routine clinical care. As a result, pre-test education is often incomplete and has significant variability across
providers resulting in inequitable care. The overall goal of this project is to develop and evaluate series of videos
to be used for pre-test education of patients who undergo tumor NGS testing as part of their clinical care. Prior
to project initiation, we conducted a provider survey to assess current provider practice as it pertains to tumor
NGS testing and patient focus groups to identify common areas of misinformation and preferences for
information presentation. Based on this provider and patient feedback and national recommendations, we will
develop 3 brief animated videos (approximately 2 minutes in length): a tumor-agnostic video (Aim 1) as well as
videos that contain tumor type-specific content for patients with metastatic lung cancer (MLC) or metastatic
breast cancer (MBC) (Aim 2). Metastatic cancer patients will be invited to view this video in-office when their
oncologists plan to order tumor NGS testing. Study participants will complete questionnaires to assess
message-specific and general genomics knowledge, tolerance of uncertainty, and provider trust both pre- and
post-video viewing. Our approach is innovative because in addition to knowledge, we will evaluate tolerance for
uncertainty and trust in provider, which have not been investigated in this context. The study is significant
because we will determine if effective pre-tumor NGS education can be achieved in a very brief, highly scalable,
video message. Our long-term goal is to study the video in a randomized-controlled, multi-center trial in
academic and community settings with diverse demographics.

## Key facts

- **NIH application ID:** 10199211
- **Project number:** 1R21CA259985-01
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Leigha Senter-Jamieson
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $395,878
- **Award type:** 1
- **Project period:** 2021-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10199211

## Citation

> US National Institutes of Health, RePORTER application 10199211, Video Intervention to Address Pre-Test Patient Education for Tumor Genomic Testing (1R21CA259985-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10199211. Licensed CC0.

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