# The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)

> **NIH NIH UM1** · JACKSON LABORATORY · 2020 · $925,466

## Abstract

PROJECT SUMMARY
In response to “NOT-RM-20-015”, we propose an urgent competitive revision to The Jackson Laboratory
Knockout Mouse Phenotyping Project (KOMP2) to develop the next generation of precision mouse models for
mechanistic discovery of SARS-CoV2 infection and therapeutic discovery of COVID-19 disease treatments.
The worldwide response to the COVID-19 pandemic has triggered a surge in demand for animal models to
understand the underlying biology and pathology of SARS-CoV-2 infection and for the preclinical development
of novel therapeutic strategies. Several mouse models have recently been reported that respond with varying
degrees to SARS-CoV-2 infection. However, given the diversity of patient outcomes, any one mouse model on
a standard inbred genetic background does not reflect the impact of host genetic context on SARS-CoV-2
infection and response to treatment. We therefore propose to create a second-generation mouse model
platform incorporating diverse genetic backgrounds, to characterize the variation in SARS-CoV-2 infection
dynamics and the development of clinically-relevant disease. The proposed project will rapidly provide the
research community with an urgently needed resource for linking the variability in COVID-19 disease outcome
with underlying host genetic features, and for developing precision therapies tailored to treat the individual
patient. Our Specific Aims are: 1) To create a panel of genetically diverse transgenic models for SARS-CoV-2
infection; 2) To characterize infectivity, phenotypic response, disease outcome, and transcriptome
heterogeneity of these models; and 3) To distribute these models and our outcome data to the scientific
community.

## Key facts

- **NIH application ID:** 10199369
- **Project number:** 3UM1OD023222-10S1
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** ROBERT E BRAUN
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $925,466
- **Award type:** 3
- **Project period:** 2011-09-16 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10199369

## Citation

> US National Institutes of Health, RePORTER application 10199369, The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) (3UM1OD023222-10S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10199369. Licensed CC0.

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