# Intermountain West Clinical Center for a Childhood Liver Disease Research Network

> **NIH NIH U01** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2021 · $488,449

## Abstract

PROJECT SUMMARY ABSTRACT
Our goal is to continue the Intermountain West Clinical Center for the Childhood Liver Disease Research
Network (ChiLDReN) at the University of Utah and Primary Children's Hospital. During the previous funding
cycle, we enrolled and retained a significant number of participants, achieved outstanding site performance,
and participated in a highly collaborative manner in all Network activities. Additionally, during the previous
funding cycle, we transferred, aligned, and processed DNA sequences in support of all Network genomics
efforts, and provided the infrastructure to share these sequence data with Network investigators via web-
based, password protected software tools. In Aim 1, we will continue to enroll infants, children, and
adolescents in current and future ChiLDReN protocols, continue to submit valuable biological specimens and
accurate and timely data, and collaboratively participate in all Network activities. In Aim 2, we propose to test
the feasibility of a biliary atresia newborn screening program in a large integrated healthcare system covering
~30,000 deliveries per year. All newborns in this healthcare system already undergo total serum bilirubin
screening as part of standard of care. We will embed a pilot study in Aim 2 to measure the impact on mothers
of newborns with a false positive newborn screen using a case-control repeated measures study design. In
Aim 3, we will perform whole genome sequencing on 10 participants and their parents in whom exome
sequencing failed to identify a molecular diagnosis. For this Aim, Network investigators will collaboratively
select subjects for whole genome sequencing using University of Utah-developed web-based tools. These
tools require no bioinformatic expertise and enable expert, Network-wide central genome review.
Accomplishing the proposed aims as a highly collaborative Center for ChiLDReN will lead to new knowledge
regarding the biochemistry, physiology, and mechanisms of childhood liver diseases, and improve the
diagnostic and management options for children afflicted with them.

## Key facts

- **NIH application ID:** 10200023
- **Project number:** 5U01DK103140-08
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Stephen L Guthery
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $488,449
- **Award type:** 5
- **Project period:** 2014-08-20 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10200023

## Citation

> US National Institutes of Health, RePORTER application 10200023, Intermountain West Clinical Center for a Childhood Liver Disease Research Network (5U01DK103140-08). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10200023. Licensed CC0.

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