# Addiction Connectome Core

> **NIH NIH P30** · UNIVERSITY OF MINNESOTA · 2021 · $489,530

## Abstract

PROJECT SUMMARY: Addiction Connectome Core
The pattern of connections between brain regions (the brain’s wiring diagram) determines how they communicate
and ultimately, how they contribute to behavior. Understanding how connectivity changes with drugs is essential
for determining the mechanisms of addiction. Recent innovations in neuroimaging have allowed scientists to
study neural connectivity across the whole brain. This work has taken place mostly in humans. At the same time,
invasive methods in animal models have led to a wealth of information on cellular changes. However, these two
approaches remain largely disconnected. The Addiction Connectome Core (ACC) will bridge this translational
gap by supporting the development of a whole-brain, multimodal connectome in mice and monkeys. The
connectome will shed light of the predictors and consequences of addiction. In addition to developing the
infrastructure and collecting core data for the connectome, we will develop a web-based searchable database
that also facilitates integration of data in mice and monkeys from multiple methodological sources before and
after exposure to two types of drugs. The ACC will integrate and make publicly available data bearing on its
mission from three sources: (1) data specifically collected for the Core, (2) data collected by the other Cores
(Structural Circuits Core and Imaging Cells during Behavior Core), and (3) data collected by extramural
scientists. As such, the core will lead to the generation and curation of a searchable, discoverable, and organized
integrated database of brain anatomy as it relates to addiction.

## Key facts

- **NIH application ID:** 10200736
- **Project number:** 5P30DA048742-02
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** BENJAMIN Y HAYDEN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $489,530
- **Award type:** 5
- **Project period:** 2020-07-01 → 2025-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10200736

## Citation

> US National Institutes of Health, RePORTER application 10200736, Addiction Connectome Core (5P30DA048742-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10200736. Licensed CC0.

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