# ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

> **NIH NIH P30** · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · 2021 · $1,310,175

## Abstract

Overall Summary/Abstract
The overall goal of this proposal is to provide an integrated, efficient synchrotron structural biology Resource to
the research community. This Resource, called ALS-ENABLE, will be located at the Advanced Light Source
(ALS) in Berkeley, California. It will provide a transparent interface to the mature structural biology technologies
at the ALS, and be designed to optimize the chances of successful structure determination for both routine and
challenging problems. Multiple access mechanisms, including on site, remote, mail-in and collaborative, will be
provided, and the users will be guided through the most appropriate routes for answering their biological
question. The Resource will leverage the substantial investment in construction and operations by other
funding agencies, industry and academia. The Resource has 3 Technology Operations Cores (TOCs) that
address specific needs in the research community: 1) rapid response crystallography, 2) high quality and high
throughput small angle X-ray scattering, and 3) specialized crystallography. A multifaceted training and
outreach program will incorporate face-to-face training, remote and online materials, and training groups. The
Resource will have a robust web presence, be represented in peer-reviewed publications, and participate in
professional meetings and workshops to promote ALS-ENABLE capabilities, recruit new users, and report
Resource technologies to the greater structural biology community. The Resource will be managed by an
administrative core, which will ensure that local, remote, and collaborative access is maintained for peer-
reviewed beamtime proposals. Based on evaluation of metrics and user feedback, we will consistently improve
the user interactions through the ALS-ENABLE web portal and the experimental resources.

## Key facts

- **NIH application ID:** 10201646
- **Project number:** 5P30GM124169-05
- **Recipient organization:** UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
- **Principal Investigator:** PAUL David ADAMS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,310,175
- **Award type:** 5
- **Project period:** 2017-09-01 → 2022-09-20

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10201646

## Citation

> US National Institutes of Health, RePORTER application 10201646, ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE) (5P30GM124169-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10201646. Licensed CC0.

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