# University of Michigan BACPAC Mechanistic Research Center

> **NIH NIH U19** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $71,055

## Abstract

PROJECT SUMMARY/ABSTRACT
The parent grant was awarded as a HEAL Initiative award, specifically as part of the Back
Pain Consortium (BACPAC) Research Program (FOA: AR19-026). The current proposal
will supplement the University of Michigan Mechanistic Research Center (UM MRC; U19
AR076734-01). The UM MRC aims to perform interventional response phenotyping in a
cohort of chronic low back pain (cLBP) patients. Interventional response phenotyping
describes the critical need to attain high quality information on each participant regarding to
which drug and non-drug therapies they do and do not respond. This need extends to
psychotherapeutic interventions, which are often used for the treatment of cLBP. This
proposal will provide one year of support for the candidate to attain focused training in
clinical pain research, including exploring differential response to psychotherapeutic
interventions. Successful completion of this work will provide the HEAL Initiative with an
extensive systematic literature review examining baseline phenotypic factors that predict
differential responsiveness to the some of the most commonly used psychotherapeutic
interventions for cLBP. The training plan will allow the candidate to: 1) understand the
theory underlying and execution of some of the most commonly used psychotherapeutic
interventions for cLBP; 2) develop expertise in phenotypic differences among patients with
cLBP that might impact interventional efficacy; and 3) understand the patient and provider
experience in order to promote the development and implementation of effective
interventions for cLBP. The candidate will work with the PIs of the parent grant, Drs. Afton
Hassett and Daniel Clauw, to complete this comprehensive training and research plan.
Combined with the rich environment of the University of Michigan, this award will provide
focused training to establish a unique niche of expertise and an independent research
program focused on intervention modification, development, and evaluation for chronic pain
patients with a history of trauma, the candidate’s primary area of interest.

## Key facts

- **NIH application ID:** 10202826
- **Project number:** 3U19AR076734-01S1
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Daniel J Clauw
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $71,055
- **Award type:** 3
- **Project period:** 2019-09-26 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10202826

## Citation

> US National Institutes of Health, RePORTER application 10202826, University of Michigan BACPAC Mechanistic Research Center (3U19AR076734-01S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10202826. Licensed CC0.

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