# Production of Pedigreed SPF Rhesus Macaques

> **NIH NIH U42** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $553,538

## Abstract

Overall
The CNPRC has maintained a pedigreed colony of Indian origin rhesus macaques for over 15
years. This Indian origin rhesus population has an extensive pedigree and is self-sustaining
with no additional animal recruitment necessary. This application proposes to expand both the
number and quality of Indian origin SPF rhesus provided to AIDS funded investigators. This
expansion and improvement in animal numbers and quality will be achieved in the following
way.
1. Expand production of SPF Level 2 animals by using smaller corn-cribs for smaller, more
 flexible breeding groups. This will provide greater control over animal production to meet
 investigator needs.
2. Transfer the current colony database on the CNPRC Vitals computer program to a new
 LabKey platform that includes electronic medical records as well as a user friendly search
function.
3. Develop improved and expanded screening and confirmatory tests for detection of SPF
agents.
4. Transition the colony pedigree analysis from the current microsatellite platform to the SNP
 panel being developed by the Genetics and Genomics Working Group (GGWC)
 Consortium of the CNPRC.
5. Expand our characterization of the microbiome and immune phenotype of both levels of
 SPF animals and provide a unique biorepository of fecal and lymphocyte samples which
 will facilitate future research projects investigating the interaction of HIV with the host
 microbiome and immune system.
The inclusion of the Biorepository Core is in response to research that suggests that knowledge
of an individual animal's microbiome may be as important as understanding its MHC haplotype
in studying both vaccine response and therapeutic intervention in AIDS related studies.

## Key facts

- **NIH application ID:** 10203147
- **Project number:** 3U42OD010990-20S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Jeffrey A Roberts
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $553,538
- **Award type:** 3
- **Project period:** 2000-09-30 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10203147

## Citation

> US National Institutes of Health, RePORTER application 10203147, Production of Pedigreed SPF Rhesus Macaques (3U42OD010990-20S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10203147. Licensed CC0.

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