# The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy

> **NIH NIH U2C** · BOSTON UNIVERSITY MEDICAL CAMPUS · 2020 · $159,890

## Abstract

In this proposal, that enhances ongoing Lung PCA studies, we propose aims to examine the protein localization, cell type specific expression, and biological pathways up-regulated with key SARS-CoV-2 viral entry genes across the various stages of lung cancer development. We will compare these results with protein expression of key SARS-CoV-2 viral entry genes as well as immune, epithelial, and endothelial cell proteins in lung tissue from patients that died from COVID-19, and from lung tissue sampled pre- and post-COVID-19 disease. Spatially characterizing the epithelium and stromal microenvironment and expression of key SARS-CoV-2 entry genes during the development of lung cancer in the central airway and the alveoli may identify potential ways to improve clinical management of this high-risk patient population and improve COVID-19 outcomes

## Key facts

- **NIH application ID:** 10203247
- **Project number:** 3U2CCA233238-01S1
- **Recipient organization:** BOSTON UNIVERSITY MEDICAL CAMPUS
- **Principal Investigator:** Steven M. Dubinett
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $159,890
- **Award type:** 3
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10203247

## Citation

> US National Institutes of Health, RePORTER application 10203247, The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy (3U2CCA233238-01S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10203247. Licensed CC0.

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