# Structural Insights into TRPV Channel Gating

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $151,873

## Abstract

PROJECT SUMMARY/ABSTRACT (parent award)
Transient receptor potential (TRP) channels play significant roles in human physiology and
facilitate essential ions’ (Na+, Ca2+) permeation through the plasma membrane. The focus of this
proposal is on the transient receptor potential vanilloid 2 (TRPV2), which plays an essential role
in cardiac function and immunity, and has been placed on the list of important anti-tumor drug
targets. Nevertheless, it remains the least studied TRPV channel at the cellular and molecular
levels. We propose to use the combination of cryo-EM, electrophysiological analysis, site-directed
mutagenesis, and computational methods to establish a detailed structural understanding of the
mechanisms of TRPV2 channel gating. In this current proposal we will focus on understanding
TRPV2 regulation by phosphoinositides, determine the mechanism of TRPV2 gating by diverse
ligands and dissect the molecular mechanism of TRPV2 interaction with cytoskeleton. Information
obtained upon completion of these studies will be potentially used for future design of TRPV2
specific therapeutics

## Key facts

- **NIH application ID:** 10204495
- **Project number:** 3R01GM103899-08S1
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Vera Moiseenkova-Bell
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $151,873
- **Award type:** 3
- **Project period:** 2013-08-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10204495

## Citation

> US National Institutes of Health, RePORTER application 10204495, Structural Insights into TRPV Channel Gating (3R01GM103899-08S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10204495. Licensed CC0.

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