# Proteomics Shared Resource

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $270,933

## Abstract

PROTEOMICS SHARED RESOURCE
Director: Larry David, Ph.D.
ABSTRACT/PROJECT SUMMARY
The Knight Cancer Institute (Knight) sponsored Proteomics Shared Resource provides advanced tools and
expertise in mass spectrometry to determine the identity, abundance, and modifications occurring in proteins.
These analyses are crucial to understanding the cause of cancer and devising improved treatments for the
disease. The resource supports a wide array of quantitative measurements including: detection of differential
protein abundance in complex cell lysates derived from primary tumors, cell lines, cultured tumor organoids and
patient-derived xenograft samples; detection of post-translation modifications, such as phosphorylation,
acetylation, ubiquitination, methylation and O-GlycNAcylation, measurement of newly synthesized proteins;
examination of protein/protein interactions; and, characterization of protein structure. The facility is a university-
wide resource that leverages strong financial and administrative support from the institution to enhance cancer
research across campus and sister institutions in a collaborative environment. It employs six highly trained
individuals, five at the Ph.D. level, and maintains four mass spectrometer systems, one that is a state-of-the-art
high-resolution Orbitrap Fusion instrument. Two of the staff provide full-time informatics support, which has a
key role in the success of the facility. In addition, the Proteomics Shared Resource benefits from participation in
the OHSU Pacific Northwest National Laboratory for Integrated Omics, which provides full access to expertise
and instrumentation available through the NIGMS BioTechnology Research Resource in Proteomics at Pacific
Northwest National Laboratory. Funds from this CCSG grant provide 10% salary support for the facility director,
and 10% salary support for the associate director. The Proteomics Shared Resource will continue to work with
the Knight and other OHSU stakeholders to identify and implement new technologies and assays that meet new
research opportunities and evolving needs, including close collaboration with the Knight in providing tools and
support needed by the new Knight early detection initiative.

## Key facts

- **NIH application ID:** 10205355
- **Project number:** 5P30CA069533-23
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** LARRY L DAVID
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $270,933
- **Award type:** 5
- **Project period:** 1997-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10205355

## Citation

> US National Institutes of Health, RePORTER application 10205355, Proteomics Shared Resource (5P30CA069533-23). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10205355. Licensed CC0.

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