# Advanced Multiscale Microscopy

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $32,582

## Abstract

ADVANCED MULTISCALE MICROSCOPY SHARED RESOURCE (AMMSR)
Co-Directors: Stefanie Kaech Petrie, PhD, and Heidi Feiler, PhD
ABSTRACT / PROJECT SUMMARY
The Advanced Multiscale Microscopy Shared Resource (AMMSR) delivers access to cutting-edge imaging
instrumentation and comprehensive technical support for cellular, subcellular and molecular imaging to
Knight Cancer Institute (Knight) members. The AMMSR integrates light microscopy and electron
microscopy (EM) services and expertise to provide comprehensive support for analysis of samples across
the full microscopy resolution spectrum. The AMMSR provides Knight Investigators: (1) coordinated
access to advanced, multiscale imaging technologies, (2) expert guidance, advice and training on sample
preparation and the use of light microscopy, EM, and correlative light and electron microscopy (CLEM)
platforms, (3) optimized workflows, (4) access to multidisciplinary faculty experts with expertise in physics,
biomedical engineering, chemistry, cancer biology and computation that provide workflow development
support for specific AMMSR instruments, (5) access to a laboratory where users can receive training, or
conduct, EM sample preparation, (6) comprehensive services provided by skilled core staff for EM sample
preparation and evaluation, optical and EM image and data acquisition, and computational analysis, (7)
access to analysis stations and software specialized for optical and EM imaging analysis, (8) access to
formal workshops and educational opportunities aimed at increasing general awareness about standard
and innovative microscopy technologies, and their successful application in basic and translational cancer
research. Recent developments in imaging technologies, including super-resolution microscopy, larger
volume 3D light microscopy EM approaches, and CLEM are providing new resources for basic and
translational research. These imaging technologies are essential tools in cancer research, leading to a
better understanding of cancer mechanisms and therapeutic resistance, as well as discovering new targets
for drug development. The comprehensive support and extensive expertise offered through the AMMSR
provides Knight Investigators with the means to understand cancer at the cellular and organismal level.

## Key facts

- **NIH application ID:** 10205356
- **Project number:** 5P30CA069533-23
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Stefanie Kaech Petrie
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $32,582
- **Award type:** 5
- **Project period:** 1997-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10205356

## Citation

> US National Institutes of Health, RePORTER application 10205356, Advanced Multiscale Microscopy (5P30CA069533-23). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10205356. Licensed CC0.

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