# Protocol Review & Monitoring System

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $74,385

## Abstract

PROTOCOL REVIEW AND MONITORING SYSTEM
ABSTRACT
The Knight Cancer Institute Protocol Review and Monitoring System (PRMS) supports the development of a
broad and scientifically relevant portfolio of clinical trials. The PRMS works to ensure that cancer patients have
access to clinical trials that are rigorous in design, feasible for timely completion, compliant with federal
guidelines, deserving of priority, and congruent with the strategic goals of the institute. Two distinct, but critical
leadership entities oversee the process: Clinical Research Disease Site Leaders (DSLs) and the Knight PRMS
committee. Proposed trials undergo initial prioritization by a DSL to assess scientific merit, alignment with the
Institute and disease site goals, available resources, feasibility for completion within specified timeframe, and
fit within a disease-level portfolio. In the second-step of the process, the PRMS reviews for relevance of the
scientific question, soundness of the design, feasibility to conduct the trial, and ability of the trial to meet an
unmet need within the disease trial portfolio. Eligible protocols receive a twice yearly scientific progress
evaluation by the PRMS to ensure accrual is on target. In addition, scientific relevance is evaluated for trials
open to accrual beyond 5 years. The PRMS has full authority to enact the scientific progress evaluation
determination. Personnel in the Knight Clinical Research Quality and Administration group provide
administrative support for PRMS, which acts independent of the OHSU Institutional Review Board (IRB) and
the Knight Data and Safety Monitoring Committee (DSMC).

## Key facts

- **NIH application ID:** 10205360
- **Project number:** 5P30CA069533-23
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Elizabeth Anderson
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $74,385
- **Award type:** 5
- **Project period:** 1997-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10205360

## Citation

> US National Institutes of Health, RePORTER application 10205360, Protocol Review & Monitoring System (5P30CA069533-23). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10205360. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*