# Quantitative Oncology

> **NIH NIH P30** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $5,536

## Abstract

QUANTITATIVE ONCOLOGY
Paul Spellman, PhD and Joe Gray, PhD, Program Co-Leaders
ABSTRACT
The Quantitative Oncology (QO) Program is a multi-disciplinary research program that was formed to facilitate
the development and application of advanced measurement capabilities from omics to imaging, combined with
computational techniques, to improve cancer management. The goal of the QO program is to enable quantitative
understanding of the behavior of cancerous cells and tissues as they evolve, respond to therapy, and interact
with their microenvironments. The QO program facilitates collaborative science organized around three research
themes: 1) Imaging – focuses on improving the understanding of cancer by analyzing components of tumors on
scales from angstrom to centimeters, including proteins to cells to tissues and using this data to inform
diagnostics and therapies; 2) Omics – employing and improving tools to analyze genomes, transcriptomes, and
proteomes to enhance our understanding of cancer; and 3) Systems Biology - focuses on elucidation of the
emergent properties of cancer-related molecular networks, the molecular and cellular phenotypes they regulate
and the evolution/adaptation of these systems during cancer development and treatment. The QO Program is
co-led by Paul Spellman, PhD, an expert in the application of translational cancer genomics and systems biology
to cancer detection and classification, and Joe Gray, PhD, an expert in systems biomedicine and imaging
technologies, with an emphasis on breast and pancreatic cancer. The QO program has 28 members who are
drawn from seven basic science departments and four clinical departments in the OHSU School of Medicine,
and the Pacific Northwest National Laboratory (PNNL). Annual direct cost funding as of January 2016 amounted
to $10,011,427 (total cost), of which $1,833,130 (total cost) was from the NCI and $6,229,652 (total cost) was
peer-reviewed. The discoveries made in this program have resulted in 251 publications, of which 31.5% are
intra-programmatic collaborations, 43.8% are inter-programmatic collaborations, and 71.3% are inter-
institutional.

## Key facts

- **NIH application ID:** 10205363
- **Project number:** 5P30CA069533-23
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** PAUL T. SPELLMAN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $5,536
- **Award type:** 5
- **Project period:** 1997-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10205363

## Citation

> US National Institutes of Health, RePORTER application 10205363, Quantitative Oncology (5P30CA069533-23). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10205363. Licensed CC0.

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