# Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Site

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $158,249

## Abstract

ABSTRACT
Urologic Chronic Pelvic Pain Syndrome (UCPPS) encompasses two highly prevalent chronic urologic pain
disorders, interstitial cystitis/ bladder pain syndrome (IC/BPS) in men and women, and chronic
prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Like many chronic pain disorders, UCPPS is
poorly understood and characterized, and treatment is mostly empirical and unsatisfactory. The
Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network was established by
the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), to study the etiology and
treated natural history of UCPPS, to inform better treatments and management of symptoms through improved
designs of clinical trials, and to identify clinical factors and research measurements to define clinically relevant
sub-groups of these patients. The MAPP Research Network is currently completing enrollment of participants
into the Trans-MAPP Symptom Patterns Study (SPS), which involves integrated phenotyping of UCPPS
participants at baseline and during a 36-month longitudinal, observational period. The SPS includes measures
to refine UCPPS subgrouping, identify symptom trends, and discover associated risk factors and biological
correlates to progression profiles. Integrated within the central protocol are studies to correlate clinical and
biological profiles with response to selected UCPPS therapies (the Analysis of Therapies during Longitudinal
Assessment of Symptoms [ATLAS] study). The current funding period ends in June 2019. We propose a
three-year funding extension, through June 2022. During the proposed three-year extension, we aim to
accomplish the following: SPECIFIC AIM 1: To Obtain an Additional 12 Months of Follow-up in the MAPP-
II SPS. The MAPP-II SPS was designed to follow UCPPS participants for up to three years. By extending the
timeframe for longitudinal follow-up from July 2019 to July 2020, the number of UCPPS participants followed
for three years in the SPS will almost double (from 198 to 384). This additional data will substantially increase
the ability of MAPP investigators to examine patterns and predictors of UCPPS symptoms over time.
SPECIFIC AIM 2: To Observe Additional ATLAS Events in the MAPP-II SPS. A major focus of the MAPP-II
SPS is to correlate individual participant phenotypes with UCPPS treatment response. To accomplish this,
SPS participants complete a phenotyping assessment before and after starting new UCPPS treatments
(ATLAS study). The additional year of follow-up will provide time for new treatment `events' to occur which can
be included in this important analysis. SPECIFIC AIM 3: To Conduct Analyses of MAPP-II Data. The current
funding period provides inadequate time for MAPP investigators to analyze the data collected as part of the
SPS. Therefore, the final two years of the proposed three-year MAPP-II extension will be devoted exclusively
to data analysis and manuscript preparation.

## Key facts

- **NIH application ID:** 10206104
- **Project number:** 5U01DK082370-13
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Jason J. Kutch
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $158,249
- **Award type:** 5
- **Project period:** 2008-09-15 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10206104

## Citation

> US National Institutes of Health, RePORTER application 10206104, Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Discovery Site (5U01DK082370-13). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10206104. Licensed CC0.

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