# Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI)

> **NIH NIH R35** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $865,732

## Abstract

Abstract
Project description: The NIA’s Alzheimer’s disease and related dementia (ADRD) Milestone 8 focuses on the
development and translation of non-pharmacologic interventions and is particularly timely given four facts.
First, existing pharmacologic agents have shown limited success. Second, the number of older adults with
ADRD is rapidly increasing. Third, mounting evidence indicates that non-pharmacologic interventions can
enhance cognition and everyday functioning, potentially delaying clinical decline. Fourth, no Milestone 8 goals
have been accomplished to date. Thus, the primary goals of the proposed Research Program on Cognition
and Neuromodulation Based Interventions (RP-CNBI) are to create a sustainable and robust infrastructure
(Goal 1), provide thorough training to the next generation of ADRD researchers (Goal 2), and develop
consensus statements and centralized analytic platforms (Goal 3). Infrastructure will include access to well
characterized older adults with ADRD, a neuroimaging platform that facilitates treatment planning and outcome
evaluation, cutting-edge equipment, a tele-video-health platform, treatment and outcome measure repositories,
dedicated staff to support studies, and pilot funding. Training provides a mixture of didactic and experiential-
based learning, including mentorship from an international panel of experts in cognition-oriented treatments
(COTs) and neuromodulation, and both salary support and travel funds for junior faculty and post-doctoral
fellows. We will hold two consensus meetings that establish practice standards and identify knowledge gaps in
years 2 (focused on COTs) and 5 (focused on neuromodulation), which directly address Milestone 8A. To
provide empirical support for these meetings, we will refine a beta-version of a centralized repository of COT
trials, known as CogTale, and develop a neuromodulation-based analogue that will be known as NeuroTale.
These repositories contain key methodological and outcome details of relevant clinical trials and automatically
calculate quality indices and effect sizes used to perform automated meta-analyses on selected data. The RP-
CNBI is extremely well positioned for success given the outstanding research environment at the University of
Michigan, including the NIA P30 funded Michigan Alzheimer’s Disease Research Center, and VA Ann Arbor
Healthcare System. The PI’s role as vice-chair (ascending to chair in 2021) of the Alzheimer’s Association
Non-pharmacologic Intervention Professional Interest Area (NPI-PIA) expands the Program’s reach by making
collaborative and mentoring opportunities available to a wide range of professionals interested in ADRD,
especially those from underserved populations and developing nations. Although physically located at the
University of Michigan, the RP-CNBI leverages the post COVID-19 integration of virtual (tele-/video-/internet-
based) to create a collaborative, widely-accessible program that is agnostic to geography. The com...

## Key facts

- **NIH application ID:** 10206704
- **Project number:** 1R35AG072262-01
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Benjamin Michael Hampstead
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $865,732
- **Award type:** 1
- **Project period:** 2021-04-15 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10206704

## Citation

> US National Institutes of Health, RePORTER application 10206704, Research Program on Cognition and Neuromodulation Based Interventions (RP-CNBI) (1R35AG072262-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10206704. Licensed CC0.

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