# Health and Functioning in New Midlife Adults: Understanding the Role of Alcohol Use, Social Environments, and Preventive Intervention over the Life Course

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2021 · $533,361

## Abstract

ABSTRACT
Significant transitions at midlife can be positive for some, but many also experience emotional challenges,
physical health declines, and high stress in adapting to new social roles. Yet, health and functioning at midlife
have received less attention compared to older ages because disease and disability remain relatively rare. This
combination of growing health challenges and low rates of disability points to opportunities for intervention to
prevent and delay more serious illness and impairment. This study addresses important gaps in knowledge to
better capitalize on these opportunities. Little is known about how midlife may be different for those now in their
40s and 50s—often labeled Generation X—who are much more diverse demographically and in their family
formation and education/career paths than prior generations. Most existing midlife research has also focused
on relatively narrow health outcomes with little consideration of the interplay of physical and mental health and
functioning in work and civic life. Recent studies showing significant health declines in new midlife cohorts
additionally underscore the need for a focus on disparities and sociodemographic differences in midlife health
and mechanisms to explain them, particularly increasing alcohol misuse and its central role in midlife health
risks. This study brings strengths to examining these issues by drawing on existing longitudinal data from the
Seattle Social Development Project (SSDP) and collecting new data in early midlife. SSDP has followed a
gender-balanced, multiethnic, and socioeconomically diverse panel of 808 participants across 15 waves from
age 10 to 39 with high retention. Data include theory-guided assessments of the social environment
throughout; unique longitudinal assessments of neighborhood environments that integrate self-report, Census,
and GIS measures; and longitudinal measures of alcohol and other substance use and disorder, mental and
physical health, and functioning in work, community, and civic life. New data augment and extend existing
measures into midlife and enable the examination of midlife-specific experiences. The study aims are to
examine (1) how sociodemographic statuses and transitions among those now entering midlife influence
comorbid health outcomes in early midlife; (2) how alcohol use, misuse and related behaviors during midlife
influence midlife health, as well as the influence of life course trajectories of alcohol use and misuse leading up
to midlife; (3) how malleable social and neighborhood environmental factors influence alcohol use and misuse
over the life course and, in turn, affect midlife health; and to (4a) examine the long-term malleability of social
environmental factors from early adolescence to midlife by testing the mechanisms of a childhood intervention
(embedded in the existing study); and (4b) identify promising adult intervention targets by conducting focus
groups with participants to help design and tailor pre...

## Key facts

- **NIH application ID:** 10206893
- **Project number:** 9R01AG069024-06A1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Marina Epstein
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $533,361
- **Award type:** 9
- **Project period:** 2021-09-30 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10206893

## Citation

> US National Institutes of Health, RePORTER application 10206893, Health and Functioning in New Midlife Adults: Understanding the Role of Alcohol Use, Social Environments, and Preventive Intervention over the Life Course (9R01AG069024-06A1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10206893. Licensed CC0.

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