Summary Support is requested for training of 5 predoctoral trainee positions per year, in a university-wide visual science training program at the systems, cellular, and molecular level. Training by thirty-six faculty mentors focuses on analysis of visual processing, and cellular, molecular and genetic aspects of the normal and diseased eye, in both basic science and disease-oriented research. Twenty-five faculty work in Systems and Computation on the visual and oculomotor systems in humans, non-human primates, and other model systems, using neurophysiology, psychophysics, behavioral analysis, brain imaging, and computational modeling (Section 1). Six faculty in Section 2 (Development and Plasticity) focus on retinal cell specification and axon guidance, eye development, the blood-retina barrier, and biophysics and plasticity of cortical dendrites and circuitry. Eight faculty have research programs that touch on Molecular/genetic Approaches to the Normal and Diseased Eye (Section 3) with primary interests in retinal degeneration, retinoid processing, and the genetics, diagnostics and therapy of retinal disorders, with a focus on age-related macular degeneration and retinal edema. Although mentors are in different departments (Biological Sciences, Psychology, Statistics, Biomedical Engineering and Radiology, Ecology, Evolution and Environmental Biology on the Morningside campus; Neuroscience on the Manhattanville campus; and Genetics, Ophthalmology, Pathology & Cell Biology, Neurology, Medicine and Pediatrics on the medical school campus, multiple collaborations on interdisciplinary themes routinely support training and advances on vision The research carried out by the mentors and trainees matches the goals in NEI’s strategic plan for eye and vision research, including the Audacious Goals Initiative and 2020 Vision for the Future. Suppport is sought for up to three years for predoctoral students who have chosen their lab and mentor in vision studies. Trainees working on thesis projects related to the vision sciences are selected from selective graduate programs such as the Doctoral Program in Neurobiology and Behavior, and Integrated Program in Cellular, Molecular and Biomedical Sciences, both of which host MD-PhD students. Through activities such as didactic courses, training in rigor and reproducabilty, thesis committees, symposia, seminars, and the Greater New York Vision Club (VisioNYC), it is expected that faculty and trainees will interact, collaborate, and produce a new generation of vision scientists who will elucidate information processing, development, and diseases of the visual system.