# Administrative Core

> **NIH NIH U19** · HARVARD MEDICAL SCHOOL · 2021 · $377,454

## Abstract

The major objectives of the Administrative Core are to institute an infrastructure that facilitates
productive interactions among the U19 Program investigators of this grant application, “Defining
regulators of immunity to acute infection using CRISPR screens” and implements our Pilot Project
program. The Administrative Core will serve as a centralized, transparent organizational structure to
provide administrative support that enables the Principal investigators and their personnel to focus on
their experimental and scientific goals. Dr. Sharpe, Program Director of the overall U19 grant, will
provide leadership and direction for operations of the Administrative Core, which will be based at
Harvard Medical School. Dr. Haining, Co-Director of this U19 grant and Core A, will lead the Pilot Grant
Program. The Administrative Core will be responsible for carrying out the following functions: a) Provide
the infrastructure for overall management and co-ordination; b) Facilitate and promote interactions and
communication between program investigators, scientific advisors and administrative personnel; c) Plan
and coordinate annual External Scientific Advisory Group (ESAG) meetings; d) Organize and
coordinate travel for ESAG members; e) Assist the Program Directors and Principal Investigators with
oversight of scientific, fiscal, regulatory and compliance matters, and with preparation and review of
yearly progress reports and financial reports; f) Implement a plan for data management/sharing among
investigators; and g) Implement the Pilot Project Program. The Administrative Core will also resolve all
conflicts that may arise. To achieve these goals, Core A has the following specific aims: Aim 1: To
provide infrastructure for overall management and coordination. Core A will provide administrative
support and coordination to promote communication and interactions among Project and Core
investigators, including the scheduling of regular teleconferences/face-to-face meetings and annual
meetings, preparing and submitting annual progress reports, providing fiscal oversight and ensuring
institutional compliance with fiscal, regulatory and scientific issues, and conflict resolution. Aim 2: To
maintain a web-based portal for data sharing via a secure Dropbox. Core A will host and manage
a secure Dropbox portal for data sharing within the U19. This easy access to data will maximize
transparency, encourage collaboration, and aid in monitoring project progress and how collaborators
are utilizing core services. Aim 3: To implement the Pilot Project Program. Core A will develop an
effective process to solicit review and award high caliber innovative Pilot Projects that use our in vivo
CRISPR platform, and monitor their progress. We will encourage applications from early career
investigators. Through these specific Aims, we will create an Administrative Core structured to
implement processes/procedures to enable the success of this highly collaborative program.

## Key facts

- **NIH application ID:** 10207345
- **Project number:** 5U19AI133524-05
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **Principal Investigator:** Arlene H. Sharpe
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $377,454
- **Award type:** 5
- **Project period:** 2017-07-05 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10207345

## Citation

> US National Institutes of Health, RePORTER application 10207345, Administrative Core (5U19AI133524-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10207345. Licensed CC0.

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