# Neurobiology and Genomics Laboratory Core

> **NIH NIH P50** · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 2021 · $313,165

## Abstract

SUMMARY – CORE 3 
The Neurobiology and Genetics Laboratory Core (NGLC) will carry out specialized assays for multiple projects 
and thereby insure optimal and comparable reliability across projects. It offers an economy of scale and moves 
resources as study priorities change. The assays fall into several major domains. Toxicology assays such as 
ones using brain tissue provide a longer time frame on most recent exposure to psychotropic drugs than body 
fluids since brain levels tend to be 10-40 times higher. This will be valuable for the postmortem brain studies in 
Project 1 where drugs may alter the results. The second domain is genetics and epigenetics. Here assays will 
include gene variants, methylation and gene expression assays. The latter domain is applicable to Projects 1, 
2 and 5. The core will assay salivary amylase and cortisol in Project 5 and the responses will also be 
correlated with findings from Projects 3 and 4. The core will prepare DNA and RNA for assay by the New York 
Genome Center checking integrity of the DNA and RNA and preparing samples with the correct concentration 
for assay. Other assays for P5 include BDNF, PUFAs, Tryptophan, Kynurenine, Quinolinic acid, Neopterin, and 
preparing samples for cytokine assays and assaying cytokines from TSST samples (IL-6, TNF-alpha, C- 
reactive protein). Since Project 6 is looking at how suicidal behavior may be predicted by the large imaging 
data sets from Projects 3 and 4, it will also consider the impact of the laboratory data from Project 5. Thus, 
findings from this core are relevant directly or indirectly to every project

## Key facts

- **NIH application ID:** 10207372
- **Project number:** 5P50MH090964-09
- **Recipient organization:** NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- **Principal Investigator:** J John Mann
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $313,165
- **Award type:** 5
- **Project period:** 2013-07-19 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10207372

## Citation

> US National Institutes of Health, RePORTER application 10207372, Neurobiology and Genomics Laboratory Core (5P50MH090964-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10207372. Licensed CC0.

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