# Core 1: Translational Core

> **NIH NIH U54** · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2021 · $709,471

## Abstract

Abstract:
The Translational Shared Research Core will provide services for both research projects in the CSB Center of
HoPE. This program investigates tumor evolution as a dynamic process arising from selection (chemotherapy
response, nutrient availability, oxygenation, therapy etc.) and phenotypic diversity resulting from genomic
instability. This core is central to the mission of the proposal as it will collect, process, grow and maintain the
patient-derived tumor cells in an effort to directly interrogate the subclonal populations found in patient tumor
cells using both genomic and experimental approaches. Specifically, these cells will provide the basis for whole
genome DNA sequencing to identify subclone populations present over the course of a patient's treatment or in
multiple metastatic lesions in the projects. RNA sequencing of these patient cells will provide analysis of
phenotypic evolution of patient cells in time or space, including the cell growth and survival pathways outlined
in the projects. Lastly, these patient cells will be used in both projects to test the relationships between
genomic and biochemical/pharmacological studies, including the ability to target key resistant cell phenotypes
with drug regimens aimed at each patient's tumor cells. Importantly, this core is responsible for the generation
of the sequencing data that provide the basis for the scientific projects above as well as sequencing the bulk
tumor for comparison with the single cell sequencing and continue optimization of the single cell sequencing
technology that is also central to the success of the scientific projects. The core will be responsible for
generation of most genomic data, and disbursement of all sequencing data to identify genomic variants,
evaluate subclonal structure, classify cellular phenotypes. These data will be made open to the scientific
community following our first publication.

## Key facts

- **NIH application ID:** 10207526
- **Project number:** 5U54CA209978-06
- **Recipient organization:** BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- **Principal Investigator:** PHILIP J MOOS
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $709,471
- **Award type:** 5
- **Project period:** 2017-05-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10207526

## Citation

> US National Institutes of Health, RePORTER application 10207526, Core 1: Translational Core (5U54CA209978-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10207526. Licensed CC0.

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