# The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center

> **NIH NIH U24** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $99,998

## Abstract

ABSTRACT
The Icahn School of Medicine at Mount Sinai (ISMMS) is strongly-positioned to engage in the mission of the
Early Phase Pain Investigation Clinical Network (EPPIC-Net), with the ISMMS Department of Neurology as the
core of our hub and spokes structure. Our strengths include: (1) the large and diverse population we care for
and have successfully recruited into clinical trials over several decades including patients with high impact pain
syndromes such as chronic low back pain (CLBP), (2) our extensive clinical trials infrastructure, including close
integration with the ISMMS CTSA and Trials Innovation Network (TIN), for which the PI of this proposal leads
pain-related activities, and (3) a cadre of highly-experienced clinical trialists in multiple specialties with
expertise across the range of studies EPPIC-Net will perform including mechanistic studies, detailed
phenotyping of pain conditions, biomarker validation studies, and phase 2 clinical trials.
We are deeply committed to using these strengths and our experienced leadership team in service of the
EPPIC-Net mission which we strongly believe will ultimately produce the non-addictive pain treatments which
our patients so desperately need. In order to ensure that our site and the entire EPPIC-Net structure is a
success, our proposal has four specific aims: (1) to streamline and optimize rapid implementation of EPPIC-
Net studies, exceeding the required minimum of 100 subjects recruited per year to EPPIC-Net studies; (2) to
ensure access to patient populations with a wide range of pain disorders, including CLBP, using a hub and
spokes model to ensure effective recruitment; (3) to provide the highest-quality protocol implementation, deep
clinical phenotyping of pain disorders, and accurate and complete data collection; and (4) to work
collaboratively with the EPPIC-Net Coordinating Centers and investigators from the NIH HEAL Partnership to
assist with development/design of clinical trials and engage in EPPIC-Net leadership.
In addition to these aims we will promote the visibility of EPPIC-Net within our institution and the larger pain
research community, use our participation in EPPIC-Net as an opportunity to train junior investigators to
become future pain clinical trials leaders and increase and disseminate knowledge about pain research
throughout our network.

## Key facts

- **NIH application ID:** 10208322
- **Project number:** 3U24NS113849-01S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Jessica Robinson-Papp
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $99,998
- **Award type:** 3
- **Project period:** 2020-09-30 → 2022-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10208322

## Citation

> US National Institutes of Health, RePORTER application 10208322, The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center (3U24NS113849-01S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10208322. Licensed CC0.

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