# Core C: Biostatistics and Bioinformatics

> **NIH NIH P50** · UNIVERSITY OF IOWA · 2021 · $205,220

## Abstract

ABSTRACT: Core C: Biostatistics and Bioinformatics. The Biostatistics and Bioinformatics Core (Core)
provides collaborative statistical and informatics support to SPORE projects, developmental projects, and other
cores. The comprehensive nature of the Core, which will have activities at both Iowa and Mayo, assures each
SPORE investigator access to expertise that includes development of study designs and analysis plans, state
of the art data analysis and interpretation, data management resources, and abstract and manuscript
preparation. The Core builds upon the innovative and time-tested procedures and systems developed by the
Division of Biomedical Statistics and Informatics at Mayo Clinic, one of the largest analytical groups in the
country whose members have collaborated on more than 8,000 clinical and basic science research studies
since 1966, as well as the Holden Comprehensive Cancer Center and the Biostatistics Department at the
University of Iowa. For this funding cycle, we added a senior Bioinformaticist staff as a Core member for the
proposed sequencing methods in the projects. The Core members will provide design and analysis support
across a range of fields, including epidemiological studies, basic sciences including translational and
immunologic correlative studies, gene microarray, gene and mutation discovery, expression analysis and
genomics, and computational biology. The Core developed the statistical plans for past studies initiated in the
SPORE, and has been actively involved in the preparation of statistical plans for the four projects in this
application. Support is also provided for the management and integration of existing and newly collected data
through consistent and compatible data handling. Areas of support include database development, data form
development and processing, data collection and entry, data archiving, quality control, and management of
information relating to gene mutation identification and genotyping data for disease linkage experiments. In the
past funding periods, the Core developed and maintained the infrastructure to link lymphoma clinical and
research databases between University of Iowa and Mayo Clinic. This system is fully functional and allows
web-based clinical registration and data entry from both sites into a common database. Furthermore, the Core
has and will continue to provide data management for all studies, to monitor adverse events in conjunction with
the Clinical Research Core, and to prepare data summaries for manuscript preparation. In summary, strengths
of the Biostatistics and Bioinformatics Core are our collaboration with each of the projects and cores, the ability
to utilize the established centralized research database as well as the operational and statistical infrastructure
already in place in the SPORE, and the breadth of expertise provided by Biostatistics and Bioinformatics
personnel.

## Key facts

- **NIH application ID:** 10208775
- **Project number:** 5P50CA097274-20
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** BRIAN JOSEPH SMITH
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $205,220
- **Award type:** 5
- **Project period:** 2002-09-11 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10208775

## Citation

> US National Institutes of Health, RePORTER application 10208775, Core C: Biostatistics and Bioinformatics (5P50CA097274-20). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10208775. Licensed CC0.

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