# (1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2022 · $306,451

## Abstract

PROJECT SUMMARY
(1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network:
application for Clinical Center
We submit this application in response to RFA-DK-16-025. We propose a Northern California APOLLO
Network based at University of California San Francisco (UCSF; the busiest kidney transplant center in the
country), University of California Davis (UC Davis), California Pacific Medical Center (CPMC) and Stanford
University. We have secured collaborations with the Association of Organ Procurement Organizations (AOPO),
United Network for Organ Sharing (UNOS) and the Scientific Registry of Transplant Recipients (SRTR). We
have also established relationships with 16 additional transplant centers in the western United States (in
Hawaii, Washington, Oregon, Nevada, Utah, Arizona, New Mexico, and Southern California) who expressed
interest in collaborating and partnering with us. We believe that our Northern California APOLLO Network will
contribute importantly to the overall goal of the Consortium to better define the relationship between APOL1
risk status and outcomes among kidney transplant recipients and donors. We will join other Clinical Centers
and obtain biological samples, genetic and clinical information from all African American kidney donors and the
recipients of those kidneys across the United States, at baseline and longitudinally, and transmit those data
and samples to the Scientific and Data Research Center (SDRC). Some strengths of our application
(”Elements Unique to This Site”) are: i) inclusion of several high-volume kidney transplant centers; ii) coverage
of a wide, contiguous geographic region; iii) multi-disciplinary research team with extensive experience in
prospective cohort studies of kidney disease and multi-center consortia; iv) cost-effective “hybrid” model study
design—jointly analyzing data collected as part of a research protocol together with data collected as part of
clinical care (or entered into a registry)—that will greatly increase the number of person-years of follow-up and
enhance study power; v) strong existing kidney transplant research infrastructure within the network, including
ongoing bio-banking at UCSF of protocol allograft biopsy samples (and concurrent blood and urine samples),
which will provide valuable information regarding renal pathology associated with APOL1 high-risk status.

## Key facts

- **NIH application ID:** 10208872
- **Project number:** 5U01DK116043-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Chi-yuan Hsu
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $306,451
- **Award type:** 5
- **Project period:** 2017-09-25 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10208872

## Citation

> US National Institutes of Health, RePORTER application 10208872, (1/1) Maximizing geographic and scientific reach through a Northern California APOLLO Network: application for Clinical Center (5U01DK116043-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10208872. Licensed CC0.

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