# RADIANT Clinic and Data Coordinating Center

> **NIH NIH U54** · UNIVERSITY OF CHICAGO · 2022 · $1,406,000

## Abstract

PROJECT SUMMARY – DISCOVERY AND ANALYSIS PROGRAM 
ABSTRACT 
Here we describe the Discovery and Analysis Program for the National Center for the Identification and Study 
of Individuals with Atypical Diabetes Mellitus. The purpose of the project is to bring together internationally 
recognized diabetes investigators with expertise in the pathophysiology and genetics of diabetes to: A) Foster 
the study of individuals with rare/atypical forms of diabetes mellitus and B) Identify and analyze rare 
phenotypes and genotypic variants of diabetes that may ultimately provide insights into more prevalent, 
heterogeneous forms of type 2 diabetes mellitus (T2DM) in the general population. The central hypothesis of 
the entire center is that the identification and study of new cases of rare/atypical forms of diabetes will 
yield greater insights into the etiology and genetic heterogeneity of T2DM. 
To reach the goals of this project, building on the track records of the participating groups over the last three 
decades, we will seek to accomplish the following Specific Aims: 
 (1) Identify and enroll individuals/families (children and adults) with rare/atypical forms of diabetes 
 utilizing a unified ascertainment protocol supported by the resources and expertise from participating 
 diabetes centers; 
 (2) Characterize novel diabetes genes/variants in the cohort associated with new rare/atypical forms of 
 diabetes and identify pre-symptomatic at-risk members of the family; and 
 (3) Characterize the cardinal features and phenotypic spectrum associated with the identified novel 
 genes/variants and evaluate age-related disease penetrance. 
The general approach is to promulgate a strategy for identification of rare/atypical forms, filter out primary 
autoimmune and known monogenic forms, and further characterize the remainder. Deeper phenotyping and 
genomic characterization of these individuals and their families in subsequent studies should help to 
characterize milder or otherwise atypical subtypes present in the spectrum of T2DM in the general population 
and reveal novel mechanistic pathways involved in the pathogenesis of diabetes. Identification of these novel 
genes and pathways may ultimately point to novel strategies for the diagnosis, treatment, and prevention of 
T2DM.

## Key facts

- **NIH application ID:** 10208877
- **Project number:** 5U54DK118612-04
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Louis H. Philipson
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,406,000
- **Award type:** 5
- **Project period:** 2018-09-10 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10208877

## Citation

> US National Institutes of Health, RePORTER application 10208877, RADIANT Clinic and Data Coordinating Center (5U54DK118612-04). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10208877. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*