# Multisystem risk profile of older adults to predict cognitive function and impairment

> **NIH NIH R03** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2021 · $157,475

## Abstract

Summary/Abstract
 This supplement proposal is in response to PA-18-591 with NOT-AG-20-022, NIA Availability of
Administrative Supplements and Revision Supplements on Coronavirus Disease 2019 (COVID-19). The parent
R03 study (AG063328) is to conduct a pilot, systematic investigation to scrutinize multi-system risk factors
(MRFs) for AD/ADRD outcomes among older adults aged 65 – 89 years. The study includes cross-sectional
(Aim 1, N= 150) and prospective (Aim 2, N= 50) aims. For Aim 2, a prospective investigation of 50 older
individuals with and without mild cognitive impairment will be performed at two time points about 10 - 12
months apart. COVID-19 pandemic and the statewide quarantine order have had and are having a significant
impact on the ongoing project such that all in-person project-related activities had been suspended since the
first week of March, and active enrollment and in-person data collection had been halted. Currently, many
eligible study participants, referred by the UCSD memory clinic with available neuropsychological test data
(“outcomes”), cannot undergo an in-person assessment of the MRFs (“risk factors”). Furthermore, the duration
of suspended on-site testing of human subjects is currently unclear, especially when abundant caution should
be taken for elderly participants with pre-existing conditions (e.g., hypertension, diabetes, etc.) that increase
the morbidity and mortality risk of COVID-19. Recruitment and formal enrollment into a 10 - 12 month
prospective study without definitive projected testing timeline is far from effective for high potential for drop-out
and loss of interest. Thus, we request supplement funds to initiate remote data collection of MRFs as well as
COVID-19-related factors that are hypothesized to affect many MRFs and the study outcomes as timely as we
are able. We propose to collect guided participant-reported and participant-collected data of MRFs through
online, mail and phone methods during a “tele-study-visit”. All five MRF domain measurements will be collected
remotely except for more sophisticated hemodynamics measures. A number of basic hemodynamic data will
be collected by self or a household/family member using a study-provided BP and O2 monitors while
instructions provided over the phone or video. The majority of psychosocial and some daily functioning
variables will be measured via online when possible and/or mailed forms. This will enable timely enrollment of
identified eligible participants and assessment of MRFs in their associations with (Aim 1) and predictability
(Aim 2) for available cognition/ADRD data. The effects of COVID-19-related isolation stress/loneliness and
PTSD symptoms on cognitive functioning and AD/ADRD risk as well as key MRFs are critical to consider as
covariates, which will be also achieved through this timely supplement. The primary purpose of this
supplement is to adapt to the COVID-19-related state of human subject testing procedures, and the aims of
this suppl...

## Key facts

- **NIH application ID:** 10209488
- **Project number:** 3R03AG063328-02S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Suzi Hong
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $157,475
- **Award type:** 3
- **Project period:** 2019-04-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10209488

## Citation

> US National Institutes of Health, RePORTER application 10209488, Multisystem risk profile of older adults to predict cognitive function and impairment (3R03AG063328-02S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10209488. Licensed CC0.

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