# Neural and motivational mechanisms of age-related change in emotion regulation > **NIH NIH R01** · WASHINGTON UNIVERSITY · 2021 · $573,721 ## Abstract PROJECT SUMMARY In the progression from middle to older-age, healthy adults typically experience improvements in their emotional functioning, such as increases in positive emotion and greater expertise in managing emotions. However, not everyone shows these age-related improvements, and the mechanisms that give rise to emotional functioning changes across adulthood are still poorly understood. The primary goal of this project is to examine the critical factors that promote positive emotional development in normative aging, and to test whether depression history might moderate this process as a key trait individual difference marker. To this end, we test our proposed Value- Based Cognitive Control Model of Emotion Regulation in ADulthood (VBCC-MERiAD). The VBCC-MERiAD framework suggests a novel insight: that interactions between reward motivation and cognitive control play a central role in understanding both the normative trajectory of emotional functioning in older adults, and conversely, why and how individuals with depression histories may get “off track”. We focus on effectively upregulating positive emotion, given that older adults prioritize positive emotion goals, and because depression is characterized by blunted reward processing. Our primary hypothesis is that positive emotion regulation (ER) abilities will rely upon the integrity of fronto-striatal circuitry (i.e., activity and connectivity between the lateral prefrontal cortex and nucleus accumbens / ventral striatum). Engagement of this circuit is predicted to reflect the utilization of reward motivation as a means of engaging cognitive control (i.e., to update and maintain ER goals). Across three Specific Aims, we propose to characterize the mechanisms of ER in middle-aged and older adults (35-74), focusing on neural and behavioral indicators of motivation and cognitive control that predict daily emotional functioning, and potential dysregulation in individuals with depression history. To achieve these aims, we will employ a multi-method design involving functional neuroimaging measures, laboratory behavioral assessments, and experience sampling methods. The sample (N=220) will include an ethnically/racially diverse set of adults (66% women) of ages 35-74, equally subdivided into two groups: healthy controls and people with depression histories. A state-of-the art neuroimaging protocol will assess brain activity associated with different ER strategies, and test for linkages with reward-motivated cognitive control. The comprehensive laboratory assessments will include diagnostic interviewing, self-report measures, cognitive functioning batteries, and a standardized ER task with measures of autonomic reactivity and behavioral coding of emotion. The experience sampling protocol will provide a naturalistic, ecologically valid assessment of participants’ emotional experiences, goals and regulatory strategies. The proposed research will dramatically extend our understanding of both normat... ## Key facts - **NIH application ID:** 10209489 - **Project number:** 1R01AG070139-01A1 - **Recipient organization:** WASHINGTON UNIVERSITY - **Principal Investigator:** Tammy English - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2021 - **Award amount:** $573,721 - **Award type:** 1 - **Project period:** 2021-04-15 → 2026-01-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10209489 ## Citation > US National Institutes of Health, RePORTER application 10209489, Neural and motivational mechanisms of age-related change in emotion regulation (1R01AG070139-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10209489. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*