# PROTEASOMAL REGULATION AND PROTEIN QUALITY CONTROL IN M. TUBERCULOSIS

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2021 · $419,333

## Abstract

Tuberculosis kills nearly 2 million people globally every year. Over the years, we have determined that the
Mycobacterium tuberculosis (Mtb) proteasome is essential to allow the tubercle bacilli to persist in animals.
Proteasomes are multi-subunit, barrel shaped proteases that degrade proteins in a highly regulated manner.
We are currently examining how proteolysis is regulated, from how proteins are tagged with the only known
bacterial protein-on-protein post-translational modification to how those tagged proteins are then delivered into
the proteasome core protease. Secondly, this proposal will seek to understand the functions of an essential
protein quality control system that is regulated by proteasomal degradation. Identifying how this system
contributes to Mtb physiology may identify new ways to combat tuberculosis infections. Thus, these studies will
reveal how a proteasome senses extracellular signals to optimize bacterial growth required for lethal infections.

## Key facts

- **NIH application ID:** 10209650
- **Project number:** 2R01AI088075-10
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Katerina Heran Darwin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $419,333
- **Award type:** 2
- **Project period:** 2010-12-01 → 2026-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10209650

## Citation

> US National Institutes of Health, RePORTER application 10209650, PROTEASOMAL REGULATION AND PROTEIN QUALITY CONTROL IN M. TUBERCULOSIS (2R01AI088075-10). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10209650. Licensed CC0.

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