# HCM Strategists proposal for: All of Us Research Program Engagement and Retention Innovators (OT2)

> **NIH NIH OT2** · PYXIS PARTNERS LLC · 2020 · $10,631,424

## Abstract

Building a participant community for the All of Us Research Program that reflects
the diversity of our country – and keeping them engaged for a decade or more –
requires purposeful precision engagement.
As the program has built an infrastructure to enroll participants, collect data, curate information, and facilitate physical
measurements and biospecimen collection (PM&B), HCM has been a vital partner since the beginning. We have built
a robust engagement infrastructure to reach, educate, and motivate individuals from communities that have been
historically underrepresented in research (UBR) to participate in the program.
Our engagement approach is grounded in best practices and fueled by the knowledge that impactful engagement
requires you to meet people where they are – not only where they live, work, and play, but also where they are
along their engagement journey. This journey begins with awareness, moves towards enrollment, and nutures ongoing
participation in the All of Us Research Program. To enable sustained, impactful engagement with potential participants,
we have built relationships with key influencers based upon trust, transparency, and bidirectional communication – the
same core values central to the All of Us Research Program.
What we have accomplished. Deep relationships across key communities have been leveraged and community-engaged
approaches used to design, develop, and deliver tools and experiences for multiple audiences. Activities
and results have been tracked to inform the iteration process to improve efficiencies. Impact and scale have been
achieved through partnerships with national organizations with the infrastructure to localize the program. Through
our trusted partnerships, we have brought the All of Us Research Program to neighborhoods, college campuses,
churches, professional conferences, festivals, and other venues where potential participants live, work, and play.
HCM has built, nurtured, and engaged a national network of 1,214 organizations. Our
relationships with these organizations resulted in 902 of them undertaking at least one learning
activity about All of Us. We created the opportunities, tools, and trainings that resulted in 412 of
these organizations taking the next steps to engage with their community in at least one activity,
which is a 46.7 percent activation rate.
Where we are going. Over the next five years, this infrastructure will be expanded to increase awareness of
All of Us, motivate individuals to enroll, engage with participants to retain them over a decade or more, and
nurture an ecosystem of researchers hungry to use the data. The individual components of the engagement
infrastructure will be housed in the new Engagement Innovation Network (Network) and fueled by a new
Engagement Incubator (EI). The EI will provide a community engagement structure that employs community-based
and participatory-engagement approaches to develop experiences for multiple audiences that can be
delivered in a va...

## Key facts

- **NIH application ID:** 10210467
- **Project number:** 7OT2OD028404-02
- **Recipient organization:** PYXIS PARTNERS LLC
- **Principal Investigator:** Ronnie TEPP
- **Activity code:** OT2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $10,631,424
- **Award type:** 7
- **Project period:** 2019-09-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10210467

## Citation

> US National Institutes of Health, RePORTER application 10210467, HCM Strategists proposal for: All of Us Research Program Engagement and Retention Innovators (OT2) (7OT2OD028404-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10210467. Licensed CC0.

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