# Non-Human Primate Core

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2021 · $258,459

## Abstract

Core H: Non-Human Primate
ABSTRACT
The Penn CFAR Nonhuman Primate (NHP) Core (Core H), located at the Tulane National Primate Research
Center (TNPRC), provides Penn CFAR investigators with unique resources to catalyze the use of NHP models
for HIV/AIDS research. Core H adds value by providing scientific expertise and collaboration for NHP studies
not available on the Penn/CHOP/Wistar campus; world-class infrastructure and technical expertise for NHP
research, including all aspects of veterinary and laboratory support; a NHP Pilot Project Program to carry out
small-scale studies and generate preliminary data for subsequent grant application; mentorship and training
for junior investigators and new-to-NHP researchers, and NHP specimens, tissues and reagents from the
range of studies ongoing at TNPRC. In the current reporting period, Core H has jump-started high impact work
on TB-HIV/SIV, vaccine development, cure research employing broadly neutralizing antibodies, pathogenesis,
and other high priority research areas. Since its establishment in 2004, Core H has supported over 30 pilot
projects including 9 in the last 5 years; during the current reporting period, 5 new NIH grants have resulted
directly from Core H pilot projects, with 2 more applications pending. The Core is led by Dr. Ronald Veazey (Core
Director) at TNPRC and Dr. James Hoxie (Co-Director) at Penn.
Core H has 5 Specific Aims: (1) To promote the use of NHP models for AIDS research by providing expertise
to CFAR investigators in project development, optimal use of animals, and data analysis, and linkage to
specialized technologies and expertise within the broader TNPRC community; (2) To support a NHP Pilot
Project Program that enables CFAR investigators to generate preliminary data needed for subsequent funding,
which is separate from but complementary to the Developmental Pilot Grant Program of Core B; (3) To provide
technical support for all aspects of NHP research including experimental procedures and state-of-the-art
laboratory protocols; (4) To provide housing, clinical care, animal husbandry, regulatory oversight
including animal welfare and biosafety compliance, and other basic services required to maintain NHPs assigned
to Penn CFAR investigators; and (5) To provide CFAR investigators with reagents, tissues, specimens and
other materials from infected or uninfected NHPs at TNPRC, including byproducts from other studies.
Looking ahead, in an innovative initiative developed in response to needs and opportunities identified by CFAR
investigators and the CFAR's Reservoirs & Tissue Immunology Scientific Working Group, Core H will create a
cohort of SIV/SHIV-infected rhesus macaques on suppressive antiretroviral drug therapy to be readily available
for proposals offered through the Core's NHP Pilot Program. Core H provides opportunities for Penn CFAR
investigators that are unique in the national CFAR network by creating this pathway for the use of powerful and
informative NHP models...

## Key facts

- **NIH application ID:** 10212201
- **Project number:** 5P30AI045008-23
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Ronald S. Veazey
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $258,459
- **Award type:** 5
- **Project period:** 1999-07-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10212201

## Citation

> US National Institutes of Health, RePORTER application 10212201, Non-Human Primate Core (5P30AI045008-23). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10212201. Licensed CC0.

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