# Emory Alzheimer's Disease Research Center

> **NIH NIH P30** · EMORY UNIVERSITY · 2021 · $398,521

## Abstract

SUMMARY/ABSTRACT: NEUROPATHOLOGY CORE 
The Emory Goizueta ADRC Neuropathology Core (NP Core) supports this ADRC and national/international 
research projects by providing comprehensive neuropathological assessment of patients dying with AD and 
related dementias (ADRD) and control subjects, and by banking and distributing brain and spinal cord tissues 
for research studies. The NP core provides expert consultation to investigators regarding case selection and 
experimental design as they relate to the use of human tissues, and also collaborates with the REC to train 
the next generation of ADRD neuropathologists and researchers. During this funding period, the NP Core 
performed brain and spinal cord autopsies on 53 UDS subjects and distributed >7000 tissue samples to 80 
investigators, leading to 120 peer-reviewed publications. Our well-characterized tissue resource enables 
highly innovative local, national, and international research projects, including the Goizueta ADRC leadership 
in the discovery of novel targets for neurodegenerative diseases using unique proteomics and proteo- 
genomics methods. With this application we continue to focus on patients with MCI, AD, and elderly controls in 
order to facilitate research into the mechanisms of onset and progression of ADRD. Consistent with our 
minority outreach programs, we also focus attention to collecting tissues from the African American population 
followed by the Clinical Core; 562 tissue samples from AA were distributed during this funding period. The NP 
Core is addressing the local and national interest in the related dementias of frontotemporal dementia 
(FTD/FTLD) and dementia with Lewy bodies (DLB). We leverage the clinical and pathological expertise of the 
NP Core leader in the overlap of FTD/FTLD with Amyotrophic Lateral Sclerosis (ALS), which are clinically 
distinct but pathologically similar diseases, some of which may coexist with AD. Emory is a member of the 
LBD Research Center of Excellence network; the NP core works to collect and distribute these valuable 
tissues for DLB researchers around the country. Our work in the related dementias provides new 
perspectives and resources for the pursuit of pathogenic mechanisms in ADRD. Together with the REC and 
other ADRC Cores, the NP Core will continue to educate students, residents, fellows, and investigators on the 
neuropathology of neurodegenerative diseases, as well as the techniques used to evaluate neuropathological 
features in human brains and animal models of disease.

## Key facts

- **NIH application ID:** 10212232
- **Project number:** 5P30AG066511-02
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Jonathan David Glass
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $398,521
- **Award type:** 5
- **Project period:** 2020-07-15 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10212232

## Citation

> US National Institutes of Health, RePORTER application 10212232, Emory Alzheimer's Disease Research Center (5P30AG066511-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10212232. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*