# Single Cell Genomics Core

> **NIH NIH P20** · DARTMOUTH COLLEGE · 2021 · $350,027

## Abstract

Core C: Single Cell Genomics (SCG) Core
ABSTRACT
High-throughput genomic, proteomic, metabolomic, and immune profiling technologies now
provide a wealth of data that can be mined to interrogate basic biological process, changes in
cellular or organismal populations, and the molecular bases of disease, at levels ranging from the
whole organism to single cells. The generation and analysis of such data is now a pillar of
research approaches and problems in the life sciences. The Center for Quantitative Biology
(CQB) will first nucleate and then grow this fusion of wet bench “omics research” with
bioinformatics at Dartmouth. Single Cell Genomics (SCG) has become an essential tool to
understand diseases involving complex biological systems including cancer, neurodegenerative
and immune/autoimmune diseases. The overall goal of the SCG core is to develop a centralized
resource within the CQB to support individual project leaders and the Dartmouth community. The
goal of this core is to implement, maintain and improve upon the technologies required to conduct
SCG experiments in a rigorous and quality controlled manner. The SCG Core will work directly
with COBRE leadership, project leaders, mentors and investigators to design robust experiments
and will implement stringent quality control and sample tracking methodologies (Aim 1) to ensure
generation of high quality, reproducible data. The SCG core will also maintain equipment and
expertise to enable isolation, capture, library preparation and sequencing of DNA and RNA from
single cells for COBRE investigators and the Dartmouth research community at large (Aim 2).
Finally, in collaboration with the Analytics Core (Core B), the SCG Core will provide the
computational infrastructure and expertise to analyze and visualize these single cell data,
expediting the process from experimental design to biological insight (Aim 3). The SCG core will
stay abreast of advancements in the field, serving as a hub of expertise and technology to
investigators campus-wide.

## Key facts

- **NIH application ID:** 10212414
- **Project number:** 5P20GM130454-03
- **Recipient organization:** DARTMOUTH COLLEGE
- **Principal Investigator:** MICHAEL L WHITFIELD
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $350,027
- **Award type:** 5
- **Project period:** 2019-08-01 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10212414

## Citation

> US National Institutes of Health, RePORTER application 10212414, Single Cell Genomics Core (5P20GM130454-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10212414. Licensed CC0.

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