# Leadership Administrative Core - LAC

> **NIH NIH U54** · JOHNS HOPKINS UNIVERSITY · 2021 · $208,802

## Abstract

SEX AND AGE DIFFERENCES IN IMMUNITY TO INFLUENZA (SADII) LEADERSHIP
ADMINISTRATIVE CORE SUMMARY
The primary goal of the SCORE on Sex and Age Differences in Immunity to Influenza (SADII) is to
systematically evaluate sex differences in vaccine-induced immune responses across the life course, with
consideration of the role that hormones, genes, age, and frailty play as independent and combined mediating
factors. The primary objective of the SADII Leadership Administrative Core (LAC) is to provide centralized
management, leadership, rigor, sharing, and dissemination of the data from the proposed Research Projects
and Cores in the SADII SCORE. This objective will be met by accomplishing three specific aims. Aim 1 will be
to provide a centralized, structured administration for all SADII SCORE investigators. The SADII SCORE will
be physically housed within the Department of Molecular Microbiology and Immunology (MMI) at the Johns
Hopkins Bloomberg School of Public Health and through the SADII Career Enhancement Core, will be
integrated with the Johns Hopkins BIRCWH program and the Johns Hopkins Center for Women’s Health, Sex,
and Gender Research (JH-CWHSGR). Aim 2 will be to provide scientific leadership for the SADII SCORE
program. The SADII LAC will ensure rigor in the research conducted, dissemination of the research results to
the greater scientific community, mentoring of junior faculty new to the study of sex as a biological variable,
and integration of the SADII SCORE into the conceptual framework and teachings at Johns Hopkins
University. Aim 3 of the SADII LAC will seek to enhance dissemination of research findings from the SADII
SCORE to the Johns Hopkins research community, broader scientific community, and governmental decision
bodies determining influenza vaccine strains and platforms. Dissemination of research findings from the SADII
SCORE will involve diverse platforms, including, but not limited to: 1) presentation and dissemination of results
at the annual JH-CWHSGR symposium, national and international meetings of professional societies, and the
annual meeting of the Organization for the Study of Sex Differences, which is an international research society,
for which Dr. Sabra Klein is President (2018-2020); 2) embedding the concept of sex as a biological variable
into the Johns Hopkins graduate and medical school curriculum; 3) establishment of a rigorous publication plan
that will ensure that publications of research, ideas, and information derived from the SADII SCORE will
appropriately acknowledge SADII for its contribution; 4) development of an informational website for the SADII
SCORE that links to other related websites both within and outside of Johns Hopkins; and 5) social media
engagement for immediate dissemination of SADII research, presentations, and activities. The Program
Director (Dr. Sabra Klein) and Co-Director (Dr. Patricia Gearhart) have the research expertise and leadership
skills to ensure that the overarching goa...

## Key facts

- **NIH application ID:** 10213169
- **Project number:** 5U54AG062333-04
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** SABRA L. KLEIN
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $208,802
- **Award type:** 5
- **Project period:** 2018-09-30 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213169

## Citation

> US National Institutes of Health, RePORTER application 10213169, Leadership Administrative Core - LAC (5U54AG062333-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10213169. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*