# Ambulatory Methods for Measuring Cognitive Change

> **NIH NIH U2C** · PENNSYLVANIA STATE UNIVERSITY, THE · 2020 · $331,308

## Abstract

Project Summary
Accurate and sensitive measurement of cognitive change is required to advance the
understanding of normative cognitive aging and improve the detection of the subtle cognitive
changes during preclinical stages of neurodegenerative diseases, such as Alzheimer's. In
response to RFA-AG-18-012, we propose to develop infrastructure for the Mobile Monitoring of
Cognitive Change (M2C2) that will provide the research community with open, flexible, and
usable tools to enable scientific progress that depends on the sensitive and accurate
measurement of cognitive change. We will build this infrastructure by accomplishing the
following aims. First, we will establish rapid iterative piloting and test development procedures
that accelerate our capacity to prototype, deploy, evaluate, and optimize candidate mobile
cognitive tests to meet psychometric, accessibility, and engagement benchmarks (Aim 1:
Iterative Design & Piloting). Second, evaluate reliability, construct validity, and longitudinal
validity of mobile cognitive testing procedures (Aim 2: Reliability & Validity) in a racially diverse
probability sample. Third, we replicate psychometric results in an independent, nationally
representative probability based sample, and create nationally representative norms (Aim 3:
Replication). And fourth, we will test our pipeline and procedures for incorporating new
measures into the mobile assessment infrastructure by evaluating novel measures for inclusion
that are nominated by investigators outside of our immediate research team (Aim 4: Extension).

## Key facts

- **NIH application ID:** 10213193
- **Project number:** 3U2CAG060408-03S1
- **Recipient organization:** PENNSYLVANIA STATE UNIVERSITY, THE
- **Principal Investigator:** Martin J Sliwinski
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $331,308
- **Award type:** 3
- **Project period:** 2018-09-15 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213193

## Citation

> US National Institutes of Health, RePORTER application 10213193, Ambulatory Methods for Measuring Cognitive Change (3U2CAG060408-03S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10213193. Licensed CC0.

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