# Interrogation of the inflammasome to identify biomarkers of progressive interstitial lung disease

> **NIH NIH R03** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $78,500

## Abstract

Project Summary
Interstitial lung disease (ILD) comprises a diverse group of diffuse parenchymal disorders with variable
degrees of inflammation and fibrosis. Among the most common fibrosing ILDs with preceding inflammation are
chronic hypersensitivity pneumonitis (CHP) and connective tissue disease-associated ILD (CTD-ILD).
Substantial proportions of patients with CHP and CTD-ILD develop a progressive phenotype, which negative
impacts survival and quality of life. Both conditions are generally treated with immunosuppressive therapy and
may now also benefit from anti-fibrotic therapy. Because some patients will remain stable without therapy,
there exists a critical need to more reliably identify CHP and CTD-ILD patients that will develop progressive
ILD and define an optimal treatment strategy for such patients. This proposal seeks to address this gap in
knowledge by employing a proteomic approach to identify inflammatory proteins predictive of progressive ILD
and differential immunosuppressant response in patients with CHP and CTD-ILD. This proposal will lay the
foundation for subsequent targeted protein investigation that will facilitate the development of biomarkers to
guide clinical decision making in this patient population.

## Key facts

- **NIH application ID:** 10213535
- **Project number:** 1R03HL157895-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Justin M Oldham
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $78,500
- **Award type:** 1
- **Project period:** 2021-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213535

## Citation

> US National Institutes of Health, RePORTER application 10213535, Interrogation of the inflammasome to identify biomarkers of progressive interstitial lung disease (1R03HL157895-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10213535. Licensed CC0.

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