# Pilot Study of a Developmental Transcriptomic Screen Comparison of Dose-Response in Tissues

> **NIH NIH N01** · BATTELLE MEMORIAL INSTITUTE · 2020 · $468,013

## Abstract

Abstract: Three sub-projects are included in this project. The model system for all is 2D or 3D HepaRG cells. The endpoint is high throughput transcriptomics. The first sub-project evaluates selected chemicals previously evaluated in 2D HepaRG, in 3D HepaRG. The second project is a time-course evaluation of the 3D HepaRG system using model chemicals. In addition, samples are included to allow comparison of cellular response to model chemcials between the 3D HepaRG system and primary human hepatocytes. The final project is an assessment of several aqueous firefighting foams in support of ongoing work to produce benchmark dose modeling data for data-poor chemicals and formulations.

## Key facts

- **NIH application ID:** 10213573
- **Project number:** 273201700005C-P00008-9999-14
- **Recipient organization:** BATTELLE MEMORIAL INSTITUTE
- **Principal Investigator:** BARNEY SPARROW
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $468,013
- **Award type:** —
- **Project period:** 2017-09-26 → 2020-09-25

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10213573

## Citation

> US National Institutes of Health, RePORTER application 10213573, Pilot Study of a Developmental Transcriptomic Screen Comparison of Dose-Response in Tissues (273201700005C-P00008-9999-14). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10213573. Licensed CC0.

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